Purchase this article with an account.
M. A. Genead, S. Pasadhika, G. A. Fishman; Retinal Nerve Fiber Layer Thickness Analysis in X-Linked Retinoschisis (XLRS) Using Fourier-Domain OCT. Invest. Ophthalmol. Vis. Sci. 2009;50(13):972.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate the presence of retinal nerve fiber layer (RNFL) defects in patients with XLRS using high speed, high resolution, Fourier domain OCT (FD-OCT).
Twenty four patients (43 eyes) with XLRS seen in the ophthalmology department at the University of Illinois at Chicago were enrolled in the study. All patients underwent a complete eye examination, including best-corrected visual acuity (BCVA) using an early treatment diabetic retinopathy screening chart (ETDRS), slit-lamp biomicroscopic examination, intraocular pressure (IOP) measurement and dilated fundus examination. FD-OCT was performed using Optovue technology. A quadrant was considered to be thinned if at least 2 of the 4 segments in the quadrant were reduced in thickness.
The average age of the 24 patients in the study was 28.8 years ± 14.7 years. Among our 24 patients with XLRS, 15 patients (62.5%) showed a thinning of the RNFL in one or more quadrants in at least one eye and 9 patients (37.5%) in both eyes. Thinning of the RNFL in 1 quadrant was seen in 12 eyes (27.9%) of 10 patients (41.7%), and thinning in 2 or more quadrants was seen in 12 eyes (27.9%) of 8 patients (33.3%). Thinning in the inferior quadrant was most commonly seen and was observed in 18 eyes (41.9%) of 12 patients (50%), followed by the temporal quadrant in 12 eyes (27.9%) of 8 patients (33.3%), nasal quadrant in 5 eyes (11.6%) of 4 patients (16.7%), and the superior quadrant in 5 eyes (11.6%) of 4 patients (16.7%).
In our cohort of XLRS patients,15 patients (62.5%) showed a thinning of the RNFL in one or more quadrants in at least one eye. Abnormal thinning was more commonly found in the inferior and temporal quadrants. The use of high speed, high resolution tools like FD-OCT as a screening modality to measure RNFL thickness would seem prudent to determine the presence of possible changes in RNFL thickness in patients with XLRS. Reductions in RNFL thickness in such patients could be relevant in their selection for future therapeutic trials.
This PDF is available to Subscribers Only