April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Retinal Hemodynamics, Systemic Markers of Endothelial Function and Inflammation in Type 2 Diabetes
L.-A. Khuu; E. Palka; J. Flanagan; T. Wong; W.-C. Lam; S. N. Markowitz; R. Devenyi; M. Brent; M. Mandelcorn; C. Hudson
Author Affiliations & Notes
  • L.-A. Khuu
    School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Dept. of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
  • E. Palka
    Dept. of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
  • J. Flanagan
    School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Dept. of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
  • T. Wong
    School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Dept. of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
  • W.-C. Lam
    Dept. of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
  • S. N. Markowitz
    Dept. of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
  • R. Devenyi
    Dept. of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
  • M. Brent
    Dept. of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
  • M. Mandelcorn
    Dept. of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
  • C. Hudson
    School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Dept. of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
  • Footnotes
    Commercial Relationships  L.-A. Khuu, None; E. Palka, None; J. Flanagan, None; T. Wong, None; W.-C. Lam, None; S.N. Markowitz, None; R. Devenyi, None; M. Brent, None; M. Mandelcorn, None; C. Hudson, None.
  • Footnotes
    Support  Canadian Institutes for Health Research (CIHR) and University of Waterloo
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1335. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Retinal Hemodynamics, Systemic Markers of Endothelial Function and Inflammation in Type 2 Diabetes
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      L.-A. Khuu, E. Palka, J. Flanagan, T. Wong, W.-C. Lam, S. N. Markowitz, R. Devenyi, M. Brent, M. Mandelcorn, C. Hudson; Retinal Hemodynamics, Systemic Markers of Endothelial Function and Inflammation in Type 2 Diabetes. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1335.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: : To investigate the associations between retinal hemodynamics, systemic markers of endothelial function and inflammation and glucose control in patients with type 2 diabetes with non-proliferative diabetic retinopathy (NPDR).

Methods: : Retinal blood flow measurements and blood serum samples were obtained from 26 NPDR type 2 diabetes subjects (mean age 61.65; SD= 8.5 years; M:F 14:12). The presence or absence of NPDR was determined by stereo fundus photography. The sample was stratified into mild-to-moderate (n=16) and moderate-to-severe (n=10) DR groups. Retinal blood flow was measured in the supero-temporal arteriole using the Canon Laser Blood Flowmeter. A minimum of 6 measurements were acquired to establish values for vessel diameter, blood velocity, max:min velocity ratio and blood flow. Blood samples were collected to derive levels of intercellular adhesion molecule (ICAM-1), vascular adhesion molecule (VCAM-1), E-selectin, von Willebrand factor (vWF) and glycosylated hemoglobin (A1c).

Results: : Diameter, velocity and flow were the same across the groups. However, max:min velocity ratio was elevated in the moderate-to-severe NPDR group (0.49 vs. 0.60, p=0.042). Max:min velocity ratio was correlated with age (r=0.425, p=0.039) and showed a marginal correlation with vWF (r=0.371, p=0.10). A marginal correlation between blood velocity and HS C-reactive protein (r=-0.395, p=0.095) was identified. The was a strong correlation between E-selectin and A1c (r=0.477, p=0.029). Not surprisingly, there were strong correlations between the measures of retinal hemodynamic parameters (r>0.41, p<0.05) and also between the endothelial function parameters (r>0.48, p<0.03).

Conclusions: : A reduction in the compliance (i.e. increased rigidity) of the arteriolar circulation with increase in severity of NPDR from mild-to-moderate to moderate-to-severe was found. A strong association between long-term glucose control and endothelial function was revealed. Markers of endothelial function and inflammation showed marginal associations with retinal hemodynamics in patients with NPDR.

Keywords: diabetic retinopathy • diabetes • inflammation 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept