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A. Raskin, A. F. Bordon, A. Gelminy, Jr., R. Ferreira, N. P. Moreno, E. M. Juricic; Comparison Between Ocular Coherence Tomography (OCT) and Fluorescein Angiography (FA) in Diabetic Patients. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1342.
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To compare the correlation between OCT and FA in diabetic patients.
FA and OCT, performed at the same day, were evaluated for the presence or absence of macular edema (ME) by 2 independent experienced examiners. We considered as ME in OCT when thickness was ≥ 301µm. Likewise in FA, when leakage was present within 3 mm diameter of the center of the fovea. This area was subdivided into 4 quadrants (superior, inferior, temporal and nasal). On FA, focal ME was considered when leakage up to 3 quadrants was detected, and diffuse ME when leakage was present in 4 quadrants. On OCT we analyzed the 5 values within the 3 mm diameter area at the retinal map analysis. We also analyzed the correlation within 3 OCT ranges: Group 1(no ME): ≤ 300µm, Group 2: 301 - 500µm, and Group 3: ≥ 501µm. Statistical analysis was performed using the chi square test.
54 eyes of 33 patients were included. Mean age was 65.4 years (range, 23 - 83 yrs). Fifteen were female and 18 were male. ME was detected by OCT in 28 (51%) eyes and among those, 21 (75%) eyes by FA (p <0.05). OCT showed absence of ME in 26 eyes (49%) and among those, 17 (66%) eyes showed no leakage on FA (p<0.05). In Group 1 (26 eyes) 17 (66%) eyes showed no leakage on FA (p<0.05). In Group 2 (20 eyes) 13 (65%) eyes showed leakage at FA. In group 3 (8 eyes) 5 (62.5%) eyes showed leakage on FA. There was no statistical difference between OCT and FA on the other 4 studied subfields
OCT is more sensitive and specific than FA in the detection of ME in diabetic patients. Disparities in the detection of either presence or absence of ME between OCT and FA was equally pronounced in the 3 OCT thickness range
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