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P. K. Gupta, J. W. Bryant, I. J. Suner; RaScaL: Pilot Study Comparing Ranibizumab + Peripheral Scatter Laser to Triamcinolone + Macular Laser in Diabetic Macular Edema Associated With Peripheral Nonperfusion on Ultra-Widefield Angiography. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1350.
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Patients with diabetic macular edema associated with peripheral nonperfusion may represent a distinct category of DME that is characterized by ischemia-driven VEGF production. A novel treatment strategy targeting the underlying pathobiology may provide effective and durable effects.
Prospective, randomized trial comparing a novel approach of angiography-directed peripheral scatter laser + ranibizumab to standard therapy with macular laser + triamcinolone. Primary outcome is visual acuity; secondary outcomes are central foveal thickness on OCT and need for retreatment at 6 months.
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Patients with DME associated with peripheral nonperfusion appear to be a distinct population. A novel treatment strategy addressing the underlying pathobiology may provide an effective and durable treatment benefit.
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