April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Comparison Amongst Corneal and Amniotic Membranne Grafts to Restore Corneal Thinning
Author Affiliations & Notes
  • C. C. Farias
    Ophthalmology, Federal Univ of Sao Paulo-UNIFESP, Sao Paulo, Brazil
  • L. B. Souza
    Ophthalmology, Federal Univ of Sao Paulo-UNIFESP, Sao Paulo, Brazil
  • L. A. Vieira
    Ophthalmology, Federal Univ of Sao Paulo-UNIFESP, Sao Paulo, Brazil
  • N. Alleman
    Ophthalmology, Federal Univ of Sao Paulo-UNIFESP, Sao Paulo, Brazil
  • J. A. P. Gomes
    Ophthalmology, Federal Univ of Sao Paulo-UNIFESP, Sao Paulo, Brazil
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1516. doi:
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      C. C. Farias, L. B. Souza, L. A. Vieira, N. Alleman, J. A. P. Gomes; Comparison Amongst Corneal and Amniotic Membranne Grafts to Restore Corneal Thinning. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1516.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the efficacy of multilayer amniotic membrane transplantation compared with corneal path for repairing corneal thinning after infection, immunologic diseases or ocular surgery.

Methods: : Prospective, comparative, interventional study of nineteen eyes of nineteen patients with corneal thinning after infection or ocular surgery. The mean age was 63,9 years old (range 47-83 years). Eight patients (42%) were female and 11 (58%) male. All patients were operated by the same surgeon and the surgical procedure was randomized in corneal or amniotic membrane graft. Ten patients underwent surgery with corneal graft (52%) and nine with amniotic membrane transplantation (48%). Patients were followed for 180 days.

Results: : All the eyes that received corneal grafts presented stability of the ocular surface with rapid reepithelialization; on the other hand, most of the eyes that received the amniotic membrane grafts had the transplanted tissue reabsorbed after approximately 30d of the surgery (%). There were a few complications: two patients who underwent surgery with corneal patch (20%) presented corneal graft rejection that was controlled with steroids. Three patients needed to be reoperated: two patients (20%) who underwent corneal graft and one patient (11%) who underwent amniotic membrane transplantation.

Conclusions: : Our results suggest that both amniotic membrane and corneal grafts are good options to be used for restoring corneal defects with thinning.

Clinical Trial: : www.clinicaltrials.gov NCT00801073

Keywords: cornea: clinical science • cornea: epithelium • cornea: stroma and keratocytes 
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