April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Comparison of Optic Nerve and Macular Thickness Among Commercially Available Fourier-Domain and Time-Domain Optical Coherence Tomography Instruments in Patients With Multiple Sclerosis and / or Optic Neuritis
Author Affiliations & Notes
  • G. M. Watson
    Ophthalmology, UC Davis - Eye Center, Sacramento, California
  • J. L. Keltner
    Ophthalmology, UC Davis - Eye Center, Sacramento, California
  • T.-G. Nguyen
    Ophthalmology, UC Davis - Eye Center, Sacramento, California
  • E. Redenbo
    Ophthalmology, UC Davis - Eye Center, Sacramento, California
  • K. Chandra
    Ophthalmology, UC Davis - Eye Center, Sacramento, California
  • E. Chin
    Ophthalmology, UC Davis - Eye Center, Sacramento, California
  • D. Harvey
    Ophthalmology, UC Davis - Eye Center, Sacramento, California
  • S. S. Park
    Ophthalmology, UC Davis - Eye Center, Sacramento, California
  • Footnotes
    Commercial Relationships  G.M. Watson, None; J.L. Keltner, None; T.-G. Nguyen, None; E. Redenbo, None; K. Chandra, None; E. Chin, None; D. Harvey, None; S.S. Park, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1530. doi:
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      G. M. Watson, J. L. Keltner, T.-G. Nguyen, E. Redenbo, K. Chandra, E. Chin, D. Harvey, S. S. Park; Comparison of Optic Nerve and Macular Thickness Among Commercially Available Fourier-Domain and Time-Domain Optical Coherence Tomography Instruments in Patients With Multiple Sclerosis and / or Optic Neuritis. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1530.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare central macular thickness (CMT) and average optic nerve retinal nerve fiber (RNFL) thickness in patients with known history of optic neuritis and / or multiple sclerosis using five commercially available optical coherence tomography (OCT) instruments.

Methods: : 45 patients (90 eyes) with history of optic neuritis and / or multiple sclerosis were imaged on the same day with five commercially available OCT instruments which included Stratus OCT, Cirrus HD-OCT (Zeiss), RTVue-100 (Optovue), Spectralis (Heidelberg), and TopCon 3D OCT-1000 (Topcon Medical Systems). With each instrument, the CMT and RNFL thickness maps were obtained and analyzed.

Results: : Among 45 patients imaged, 10 patients were excluded due to concurrent retinal disease or poor OCT image quality. Among 35 patients (70 eyes) included in our analysis, the mean +/- SD of the respective CMT and RNFL thickness were as follows for the five OCT instruments; Right Eye: Stratus (186 +/- 23, 93 +/- 13), Cirrus (257 +/- 23, 85 +/- 13), RTVue (247 +/- 23, 96 +/- 13), Spectralis (274 +/- 43, 89 +/- 16), Topcon (226 +/- 23, 102 +/- 12), and Left Eye: Stratus (187 +/- 21, 90 +/- 15), Cirrus (255 +/- 24, 84 +/- 13), RTVue (247 +/- 21, 94 +/- 15), Spectralis (268 +/- 25, 87 +/- 18), Topcon (226 +/- 23, 100 +/- 13). Randomized block analysis of variance revealed significant differences in CMT and RNFL thickness across instruments (p<0.001). Of the 89% female patient population, 86% were diagnosed with multiple sclerosis, 71% with optic neuritis, and 57% with both.

Conclusions: : This cross sectional comparative study illustrates that differences exist in CMT and RNFL thickness measurements by different commercially available OCTs in patients with optic neuritis and / or multiple sclerosis. These differences likely result from difference in data acquisition (time-domain versus fourier-domain) and software among the various instruments.

Keywords: imaging/image analysis: clinical • neuro-ophthalmology: optic nerve 
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