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H. Zhao; Optical Ensemble Analysis of the Potential Optical Outcomes of Aspheric IOLs. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1624.
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© ARVO (1962-2015); The Authors (2016-present)
To analyze the optical outcomes of three aspheric intraocular lenses (IOLs) compared to a spherical IOL using a clinically-oriented Monte Carlo ensemble analysis of post-operative ocular parameters.
Monte Carlo simulation was used to generate the optical outcomes of three groups of aspheric IOLs (the 1st group (G1) with an acrylic IOL that fully corrects the average spherical aberration (SA) of pseudophakic eyes, the 2nd group (G2) with an IOL made from different acrylic material that partially corrects the ocular SA, and the 3rd group (G3) with a silicone IOL that corrects only the lens SA) by computing their MTF values from an ensemble of clinically-relevant ocular parameters including corneal power and asphericity, pupil size and decentration, IOL decentration and tilt. A control group (GC) with a silicone spherical IOL was also used. Clinical trials were simulated using ZEMAX (ZEMAX Development Corporation, Bellevue, WA, USA) and the Piers-Norrby-Mester average cornea eye model (Optics Letters; 29(7): 733-735).
The post-op optical outcomes of aspheric IOL groups in the simulated clinical trials varied from the control. The outcome variation across the population was different for the 4 lens groups and overlaps each other. GC and G3 had the least standard deviation, followed by G2 and G1. The outcomes also showed that G1, G2, and G3 had a potential optical benefit which level, however, varied significantly between groups. The outcome in G1 in mesopic light was significantly better than that in GC. G2 and G3 had better outcomes than GC but were not deemed to be significantly better. Chromatic aberration also played an important role in the potential optical outcomes.
The simulated optical outcomes are consistent with clinical findings. All three aspheric IOLs showed better average results than the spherical IOL in mesopic light but with different significance levels. The aspheric IOL with less material dispersion that targets full correction of ocular SA provided the best possible average optical outcome in the pseudophakic eyes. The overlap among the simulated optical outcomes of IOL groups suggested that in practice the optical outcome of these aspheric IOLs may overlap each other.
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