April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Human Cone Anatomy in Macular Disease: Adaptive Optics Scanning Laser Ophthalmoscopic Imaging of Cones in Idiopathic Macular Telangectasia
S. D. Schwartz; A. Kaines; J. Duncan; B. Lujan; S. Sundquist; S. A; M. Sato; A. Roorda
Author Affiliations & Notes
  • S. D. Schwartz
    Ophthalmology, Jules Stein Eye Inst/UCLA, Los Angeles, California
  • A. Kaines
    Ophthalmology, Jules Stein Eye Inst/UCLA, Los Angeles, California
  • J. Duncan
    Ophthalmology, University of California, San Francisco, San Francisco, California
  • B. Lujan
    Ophthalmology,
    University of California, Berkeley, Berkeley, California
  • S. Sundquist
    Ophthalmology, University of California, San Francisco, San Francisco, California
  • S. A
    Ophthalmology, University of California, San Francisco, San Francisco, California
  • M. Sato
    Ophthalmology, University of California, San Francisco, San Francisco, California
  • A. Roorda
    Optometry,
    University of California, Berkeley, Berkeley, California
  • Footnotes
    Commercial Relationships  S.D. Schwartz, None; A. Kaines, None; J. Duncan, None; B. Lujan, None; S. Sundquist, None; S. A, None; M. Sato, None; A. Roorda, None.
  • Footnotes
    Support  Price Foundation, Lowy Foundation, NIH EY014375, NSF AST-9876783 NIH Grant EY002162, Research to Prevent Blindness, Foundation Fighting Blindness, The Bernard A. Newcomb Macular Degeneration Fund, Tha
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1656. doi:
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      S. D. Schwartz, A. Kaines, J. Duncan, B. Lujan, S. Sundquist, S. A, M. Sato, A. Roorda; Human Cone Anatomy in Macular Disease: Adaptive Optics Scanning Laser Ophthalmoscopic Imaging of Cones in Idiopathic Macular Telangectasia. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1656.

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Abstract

Purpose: : To investigate the photoreceptor (cone) array in different stages of idiopathic macular telangectasia (IMT) with the adaptive optics scanning laser ophthalmoscope (AOSLO). This device can acquire high-fidelity en face scans of the retina with two-micron lateral resolution.

Methods: : In this observational case series, high-resolution retinal images of 15 eyes from 8 patients were obtained with AOSLO. Conventional clinical measures included spectral domain OCT (SDOCT), color fundus photos, autofluorescence and fluorescein angiograms. Observational measures of AOSLO images included the presence or absence and the reflectivity of the cone array. Images were quantified by measuring cone spacing relative to the foveal center and making statistical comparisons with data from over 20 normal healthy eyes.

Results: : AOSLO imaging allowed visualization of cone arrays in IMT. Characteristic patterns of the 8 patients included focal areas of cone loss (which were confirmed with SDOCT) surrounded by regions of contiguous cone arrays with spacing and appearance that was no different from healthy eyes. Abnormal cone mosaics were observed only in regions proximal to the paracentral regions of cone loss and were often associated with hyper-reflective cones.

Conclusions: : This study suggests cone anatomy can be studied in various stages of human macular disease (IMT). Statistical analyses of visible cone densities may correlate with disease severity. Serial imaging of cone spacing, cone reflectivity and regions of cone dropout by AOSLO may provide a meaningful endpoint able to quantitate disease progression or response to intervention.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • macula/fovea • photoreceptors 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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