April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Correlation Between Adaptive Optics Scanning Laser Ophthalmoscopy and Spectral Domain Optical Coherence Tomography in Macular Telangiectasia
B. J. Lujan; P. F. Stetson; J. L. Duncan; A. Kaines; S. Sundquist; A. Soloyevev; M. Sato; S. D. Schwartz; A. Roorda
Author Affiliations & Notes
  • B. J. Lujan
    School of Optometry, University of California, Berkeley, Berkeley, California
  • P. F. Stetson
    Carl Zeiss Meditec, Inc, Dublin, California
  • J. L. Duncan
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California
  • A. Kaines
    Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California
  • S. Sundquist
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California
  • A. Soloyevev
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California
  • M. Sato
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California
  • S. D. Schwartz
    Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California
  • A. Roorda
    School of Optometry, University of California, Berkeley, Berkeley, California
  • Footnotes
    Commercial Relationships  B.J. Lujan, Carl Zeiss Meditec, Inc., F; P.F. Stetson, Carl Zeiss Meditec, Inc., E; J.L. Duncan, None; A. Kaines, None; S. Sundquist, None; A. Soloyevev, None; M. Sato, None; S.D. Schwartz, None; A. Roorda, Carl Zeiss Meditec, Inc., F; Univ of Houston and Univ of Rochester, P.
  • Footnotes
    Support  NIH Grants K12EY017269-04, EY002162, EY014375, Price Foundation, Lowy Foundation, Research to Prevent Blindness, Foundation Fighting Blindness, That Man May See, Inc., Hope for Vision
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1657. doi:
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      B. J. Lujan, P. F. Stetson, J. L. Duncan, A. Kaines, S. Sundquist, A. Soloyevev, M. Sato, S. D. Schwartz, A. Roorda; Correlation Between Adaptive Optics Scanning Laser Ophthalmoscopy and Spectral Domain Optical Coherence Tomography in Macular Telangiectasia. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1657.

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Abstract

Purpose: : The adaptive optics scanning laser ophthalmoscope (AOSLO) can acquire high-fidelity en face scans of the retina with two micron lateral resolution. While it is confocal, its axial resolution is between 60-100 microns. By comparison, spectral domain optical coherence tomography (SDOCT) is limited in its lateral resolution by ocular aberrations, but commercial systems are capable of acquiring a dense macular volume with five micron axial resolution. We investigate the use of these complementary systems to visualize photoreceptor anatomy in patients diagnosed with macular telangiectasia.

Methods: : Best-corrected visual acuity, fundus examination, fluorescein angiography, fundus autofluorescence, SDOCT (Cirrus HD-OCT, Carl Zeiss Meditec, Inc) and AOSLO were performed in 9 eyes of 6 patients with macular telangiectasia. Image processing and registration of the resulting images were used to analyze macular photoreceptors.

Results: : In SDOCT images the photoreceptor inner-segment/outer-segment junction (IS/OS) is highly reflective and can be used as a proxy for photoreceptor (PR) integrity. Topographical analysis of the IS/OS layer by manual segmentation of each B-scan, using software on the SDOCT system and a proprietary automated algorithm, demonstrated patchy areas of PR loss. In areas where the IS/OS junction was absent on SDOCT, no unambiguous photoreceptors were visualized in registered AOSLO images. Regions where intact IS/OS were present correlated with areas where cones were unambiguously visualized using AOSLO. Furthermore, distinct transition zones between intact and absent IS/OS correlated with AOSLO images.

Conclusions: : SDOCT analysis of patients with macular telangiectasia demonstrated regions of apparent photoreceptor disruption which were highly correlated with regions where cones were not visualized using AOSLO. This pilot study demonstrates the synergistic nature of these high-resolution retinal imaging systems.

Keywords: imaging/image analysis: clinical • retina • photoreceptors 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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