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T. Nouchi, S. Makita, M. Miura, K. Kawana, F. Okamoto, T. Oshika, Y. Yasuno; Standard- and High-Resolution Investigation of Age-Related Macular Degeneration by High-Penetration Optical Coherence Tomography With One Micrometer Probe. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1658.
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Age-related macular degeneration (AMD) is frequently associated with hyper-scattering materials in its optical coherence tomography (OCT) image. Since AMD is developed from retinal pigment epithelium (RPE) and choroid, it is crucial to investigate the pathologies beneath this scattering mass. Although OCT is a useful tool, it had been difficult to investigate the sub-hyper-scattering pathologies. In this paper, we present our newly developed standard- and high-resolution high-penetration OCT (SR-HPOCT and HR-HPOCT), and demonstrate their applications to AMD.
17 eyes of 12 subjects of AMD and polypoidal choroidal vasculopathy (PCV) were examined both by SR- and HR-HPOCT. In addition to the HPOCT examinations, the eyes were examined by a standard clinical protocol including 3D OCT-1000 (TOPCON, center wavelength: 840 nm). HPOCTs are custom prototypes built by authors. SR-HPOCT is based on swept-source OCT technology and with a center wavelength of 1.06 um, a depth resolution of 11.0 um, and a scanning speed of 30,000 A-lines/s. HR-HPOCT is based on a full-range spectral domain OCT technology, with a 1.04 um center wavelength, a 7.4 um depth resolution, and a scanning speed of 46,900 A-lines/s. The sensitivities of both OCT exceed 97 dB.
Seven eyes of 6 subjects were appeared with type-I choroidal neovascularization (CNV), 4 eyes of 4 subjects were type-II CNV, 5 eyes of 3 subject showed PCV, and residual 1 eye showed deformation of RPE. Hyper scattering cluster were observed beneath pigment-epithelium detachment (PED) in 13 eyes (right figure). A layer, which may corresponds Bruch’s membrane, was clearly observed beneath the hyper-scattering mass in 10 of the 13 eyes (left figure). In contrast to the case of the PED with hyper-scattering cluster, no hyper-scattering matter was found in a serous PED.
HPOCT is a useful tool to investigate pathologies beneath hyper scattering matter of AMD.
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