Purchase this article with an account.
E. R. Kelly, J. Plat, G. R. M. M. Haenen, A. Bast, R. P. Mensink, T. T. J. M. Berendschot; The Effect of Modified Eggs on Macular Pigment. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1711.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
There is increasing evidence that suggests a possible beneficial effect of lutein and zeaxanthin on macular degeneration. Eggs, containing ample amounts of cholesterol, present themselves as a suitable vehicle to attain adequate absorption. We here present the results of a trial on the effect of daily egg consumption on plasma levels and macular pigment optical density (MPOD).
For this double blinded, three months interventional trial, 80 healthy subjects were recruited and randomized into 4 groups, stratified for age and gender. Group 1 consumed lutein-enriched eggs, group 2 zeaxanthin-enriched eggs, whereas group 3 had normal eggs daily. The control group 4 was not blinded and received no product. Serum lutein, zeaxanthin and MPOD were measured at baseline, week 6-7 and at endpoint. MPOD measurements were performed using the macular pigment screener (MPS), the macular pigment reflectometer (MPR), and a scanning laser ophthalmoscope (SLO).
Baseline characteristics were comparable in the four groups. A regression analysis with serum lutein endpoint concentration as the dependent variable, and baseline serum lutein concentration and groups as the independent variables showed the lutein-enriched eggs to significantly increase lutein plasma levels (P<0.001). A similar analysis for zeaxanthin showed the zeaxanthin-enriched eggs to cause a significant increase of the plasma zeaxanthin concentration (P<0.001). A regression analysis of the SLO measurements with endpoint MPOD as dependent, and baseline MPOD and diets as independents showed a significant contribution of normal egg, lutein- , and zeaxanthin-enriched eggs as compared to the control group (P=0.044, P=0.019, and P=0.014 respectively). The MPR-lutein measurement also showed the lutein-enriched eggs to contribute to a significant increase in MPOD (P= 0.048).
In this study, we showed a significant effect of the lutein- and zeaxanthin-enriched eggs on the plasma concentrations of lutein, zeaxanthin, and MPOD. This result poses the enriched-eggs as an effective vehicle for the absorption of lutein and zeaxanthin.
Clinical Trial: :
This PDF is available to Subscribers Only