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S. Beatty, M. Stevenson, J. M. Nolan, J. Woodside, The CARMA Study Group, U. Chakravarthy; Longitudinal Relationships Between Macular Pigment and Serum Lutein in Patients Enrolled in the CARMA Clinical Trial (Carotenoids and Co-antioxidants in Age-Related Maculopathy). Invest. Ophthalmol. Vis. Sci. 2009;50(13):1719.
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To report on the relationships between estimates of macular pigment measured by Raman spectroscopy and serum lutein (L) in patients enrolled in the CARMA study (Carotenoids and Co-antioxidants in Age-Related Maculopathy).
CARMA is a randomised double-masked prospective trial of L, zeaxanthin (Z), and co-antioxidants zinc, copper, vitamin E and vitamin C (Active; A) versus placebo (P). A total of 433 participants were randomised to A or P in two clinical centres (Belfast, Northern Ireland and Waterford, Republic of Ireland). Serum antioxidants were measured at every visit. Raman counts (RC) were obtained by spectroscopy. A general linear model was used to construct an analysis of covariance between RC and log serum L within patients across time.
Mean change in RC from baseline at 12 months was +26 in the A group, whereas in the P group a steady decline was observed culminating in a mean fall to -61 counts. This difference was highly significant (p=0.006). In the longitudinal analysis conducted without reference to treatment assignment, a ten-fold increase in serum L resulted in a positive differential of +70 RC.
Supplementation with L and Z and co-antioxidants arrested the decline in RC observed over time in study eyes of participants at high risk of progression to late AMD .
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