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H.-W. Kwak, E.-S. Kim, S.-Y. Yu; Result of Combination Therapy of Photodynamic Therapy and Intravitreal Ranibizumab Injection in Exudative Age-Related Macular Degeneration (amd). Invest. Ophthalmol. Vis. Sci. 2009;50(13):1911.
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To investigate the result of combination therapy of photodynamic therapy and intravitreal ranibizumab injection in Korean patients with exudative AMD
We evaluated 13 eyes of 13 patients with exudative age-related macular degeneration. First day of treatment, photodynamic therapy and intravitreal ranibizumab injection was performed at the same time, then 2 more injection at an interval of 4 weeks. After this, visual acuity, foveal thickness, fundus autofluorescence, PHP examination was recorded, and additional treatment was done when it needed.
Average visual acuity (ETDRS) before treatment is 0.88, and 0.76, 0.60, 0.50, 0.56 after 1 month, 3 month, 6 month, 12 month after treatment. At 12 month after, Visual acuity improved by about 19.4 letters. Foveal thickness before treatment is 300um, and 167 um, 125 um, 141 um, 138 um after treatment. There is no specific differences in fundus autofluorescene finding before and after treatment. The change of metamorphopsia was measured by PHP. P-value increased and the area of metamorphopsia decreased. Total injection time is 4.21 during 12 month.
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