Purchase this article with an account.
K. W. Small, R. Silva-Garcia, Registry Investigator Groups; Treating Wet AMD With Verteporfin PDT in Triple or Double Combination Therapy: Results of Two Visudyne® Registry Databases. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1925. doi: https://doi.org/.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To assess real-world treatment outcomes of verteporfin PDT (vPDT) as double (with an anti-VEGF agent) or triple (with an anti-VEGF agent plus a corticosteroid) therapy in patients with CNV due to AMD. Results from these registries may provide a basis for further investigations to address questions such as: does vPDT combined with an anti-VEGF antibody (with or without steroid treatment) provide a visual acuity (VA) benefit similar to monthly ranibizumab, with acceptable safety, but with fewer treatments?
Retrospective analysis of data from 2 registries. Registry 1: patients received bevacizumab within ±14 days of vPDT. Registry 2: patients received either (1) ranibizumab within ±14 days of vPDT, or (2) vPDT combined with ranibizumab or bevacizumab and a corticosteroid, where all 3 components were delivered within 14 days of each other. Physicians entered data into secure Web-accessed databases. Inclusion criteria: prior treatment of subfoveal CNV due to AMD administered at least once as described. Follow-up data: visual acuity (VA) assessment, dilated ocular examination, intraocular pressure check, serious adverse event reporting, and additional treatment(s), if any.
In Registry 1 and 2, respectively, 1073 and 539 patients had at least 6 months of follow-up, and patients had mean baseline VA of 0.967 logMAR (20/185) and 0.928 logMAR (20/170). A mean of 0.6 and 0.4 vPDT retreatments and 2.2 and 2.0 anti-VEGF retreatments were given over a mean follow-up period of 15.0 and 11.2 months, respectively. By 12 months of follow-up, patients gained a mean VA of 6.0 letters (n=701) and 5.7 letters (n=248), respectively. In the 2 registries combined, 11 ocular and 36 non-ocular serious adverse events were reported as of April 2008. Most events (42/47, 89%) were judged by investigators as not related to any treatment, while 4 of the ocular events were judged related to bevacizumab treatment alone and 1 ocular event was judged related to both PDT and bevacizumab treatment.
Results from the over 1600 patients in these registries provide preliminary support that vPDT combined with an anti-VEGF agent (with or without corticosteroid treatment) appears to provide a VA benefit similar to monthly ranibizumab, with acceptable safety, but requiringfewer retreatments. Randomized controlled trials are underway that may answer questions raised by these analyses.
This PDF is available to Subscribers Only