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C. Kee, J.-M. Hwang, M. Lee, T.-W. Kim, H.-K. Choungv; Slow-Releasing All-Trans-Retinoic Acid in Polytetrafluoroethylene/Polylactide-Co-Glycolide Laminate Delays Adjustment After Strabismus Surgery in Rabbit Model. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1989.
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To determine the usefulness of slow-releasing all-trans-retinoic acid (ATRA) in polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate for delayed adjustable strabismus surgery.
A prospective, masked-observer, controlled study was performed in 25 rabbits. Fifty rabbit eyes were divided randomly into three groups. After a recession of the superior rectus muscle (SRM), a PTFE/PLGA laminate containing ATRA, PTFE alone, or balanced salt solution was applied beneath and over the SRM in the PTFE/PLGA-ATRA group (group ATRA), the PTFE group (group PTFE) and the control group, respectively.
At 5 weeks postoperatively, group PTFE and group ATRA showed better adjustability than the control group. In addition, there was less adhesion in group PTFE or group ATRA than the control group in terms of adhesion between SRMs and conjunctivae at 5 weeks postoperatively. Only group ATRA showed less adhesion than the control group in terms of adhesion between SRMs and sclerae at 5 weeks postoperatively.
Slow-releasing ATRA in PTFE/PLGA was found to reduce adhesion and allowed delayed adjustment in most eyes for up to five weeks postoperatively.
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