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N. Ishikawa, T. Miyamoto, S. Saika; An Inihibitory Effect of Coating of the Surface of an Acrylic Intraocular Lens With Mpc Polymer on Foreign-Body Reaction-Related Cell Adhesion in Rabbits. Invest. Ophthalmol. Vis. Sci. 2009;50(13):2085.
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To evaluated whether cell adhesion to the intraocular lens surface was suppressed by coating an intraocular lens (IOL) surface with 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer. MPC polymer has hydrophilic characteristic with an interpolymerization body of phosphatide resemblance structure.
An AF1 intraocular lens (VA60BB, HOYA , Japan) was coated with MPC polymer. Phacoemulsification and aspiration were performed and an MPC-coated IOL (group of MPC) or a non-coated IOL (group of non-coats) was implanted into an eye of each of 18 adult albino rabbits. After up to 1or 3 months, the animals were killed and the IOLs were removed. After hematoxylin and eosin staining, we counted the number of cells that adhere to the IOL surface in the IOL center (2×2mm) area and examined statistics in Mann-Whitney U-test.
The number of cell adhesion to the central area of IOLs was a significantly less in the group of MPC-IOL than that of the non-coat IOL group (p <0.05) at 1 month post-operatively. At 3 months there was no significant difference in the numbers of adherent cells between 2 groups.
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