April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Polymorphism in the WRN Gene in Patients With Senile Cataract
M. Ehrenberg; O. Dratviman; B. R. Avraham-Lubin; N. Goldenberg-Cohen
Author Affiliations & Notes
  • M. Ehrenberg
    Ophthalmology department, Rabin Medical Center, Petah Tiqwa, Israel
    Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
  • O. Dratviman
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    The Krieger Eye Research Laboratory, Felsentein Medical Research Center, Tel Aviv University, Petah Tiqwa, Israel
  • B. R. Avraham-Lubin
    Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    The Krieger Eye Research Laboratory, Felsentein Medical Research Center, Tel Aviv University, Petah Tiqwa, Israel
  • N. Goldenberg-Cohen
    The Krieger Eye Research Laboratory, Felsentein Medical Research Center, Tel Aviv University, Petah Tiqwa, Israel
    Pediatric Ophthalmology Department, Schneider Children's Medical Center, Petah Tiqwa, Israel
  • Footnotes
    Commercial Relationships  M. Ehrenberg, None; O. Dratviman, None; B.R. Avraham-Lubin, None; N. Goldenberg-Cohen, None.
  • Footnotes
    Support  The Krieger Fund, Baltimore, MD, and The Claire and Amedee Maratier Institute for the study of visual disorders and blindness, Tel Aviv University.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 2122. doi:
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      M. Ehrenberg, O. Dratviman, B. R. Avraham-Lubin, N. Goldenberg-Cohen; Polymorphism in the WRN Gene in Patients With Senile Cataract. Invest. Ophthalmol. Vis. Sci. 2009;50(13):2122.

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Abstract

Purpose: : The aim of this study was to investigate the incidence of the C1367T (rs1346044) polymorphism in WRN gene in patients with age-related cataract.

Methods: : Anterior lens capsule material was collected during surgery from 66 patients with senile cataract. All epidemiological data were collected. DNA was extracted, amplified by polymerase chain reaction, and sequenced for WRN gene. DNA samples were screened for polymorphism in rs1346044 WRN gene using restriction enzymes followed by sequencing.

Results: : Twenty six males and 40 females were included; mean age was 74.5 ± 9 years. Genotypic frequencies of T/T and T/C were 68% and 32% respectively. No C/C phenotype was found. Eight patients had myocardial infarct; 7 cardiovascular accident and 7 had various tumors, two of them breast cancer.

Keywords: cataract • genetics • gene/expression 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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