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M. Ehrenberg, O. Dratviman, B. R. Avraham-Lubin, N. Goldenberg-Cohen; Polymorphism in the WRN Gene in Patients With Senile Cataract. Invest. Ophthalmol. Vis. Sci. 2009;50(13):2122.
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The aim of this study was to investigate the incidence of the C1367T (rs1346044) polymorphism in WRN gene in patients with age-related cataract.
Anterior lens capsule material was collected during surgery from 66 patients with senile cataract. All epidemiological data were collected. DNA was extracted, amplified by polymerase chain reaction, and sequenced for WRN gene. DNA samples were screened for polymorphism in rs1346044 WRN gene using restriction enzymes followed by sequencing.
Twenty six males and 40 females were included; mean age was 74.5 ± 9 years. Genotypic frequencies of T/T and T/C were 68% and 32% respectively. No C/C phenotype was found. Eight patients had myocardial infarct; 7 cardiovascular accident and 7 had various tumors, two of them breast cancer.
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