April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Anterior and Posterior Surface Irregularity of the Cornea Before and After Descemet’s Stripping Endothelial Keratoplasty and Its Correlation With Postoperative Visual Acuity and the Duration of Bullous Keratopathy
Y. Tomita; T. Yamaguchi; K. Negishi; K. Yamaguchi; M. Dogru; Y. Uchino; S. Shimmura; K. Tsubota
Author Affiliations & Notes
  • Y. Tomita
    Opthalmology, Keio University School of Medicine, Sinnjyuku-ku, Japan
  • T. Yamaguchi
    Opthalmology, Keio University School of Medicine, Sinnjyuku-ku, Japan
  • K. Negishi
    Opthalmology, Keio University School of Medicine, Sinnjyuku-ku, Japan
  • K. Yamaguchi
    Opthalmology, Keio University School of Medicine, Sinnjyuku-ku, Japan
  • M. Dogru
    Opthalmology, J&J Ocular Surface and Visual Optics Department, Keio University School of Medicine, Sinnjyuku-ku, Japan
  • Y. Uchino
    Opthalmology, Keio University School of Medicine, Sinnjyuku-ku, Japan
  • S. Shimmura
    Opthalmology, Keio University School of Medicine, Sinnjyuku-ku, Japan
  • K. Tsubota
    Opthalmology, Keio University School of Medicine, Sinnjyuku-ku, Japan
  • Footnotes
    Commercial Relationships  Y. Tomita, None; T. Yamaguchi, None; K. Negishi, None; K. Yamaguchi, None; M. Dogru, None; Y. Uchino, None; S. Shimmura, None; K. Tsubota, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 2196. doi:
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      Y. Tomita, T. Yamaguchi, K. Negishi, K. Yamaguchi, M. Dogru, Y. Uchino, S. Shimmura, K. Tsubota; Anterior and Posterior Surface Irregularity of the Cornea Before and After Descemet’s Stripping Endothelial Keratoplasty and Its Correlation With Postoperative Visual Acuity and the Duration of Bullous Keratopathy. Invest. Ophthalmol. Vis. Sci. 2009;50(13):2196.

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Abstract

Purpose: : To evaluate the anterior and posterior surface irregularity of the cornea before and after Descemet’s stripping endothelial keratoplasty (DSEK) and its correlation with postoperative visual acuity and the duration of bullous keratopathy (DBK).

Methods: : This clinical study comprised 24 consecutive eyes of 23 bullous keratopathy patients. Corneal data were acquired using a rotating Scheimpflug camera (Pentacam, Oculus) before and 3 months after DSEK. Anterior and posterior corneal elevation data were decomposed into a set of Zernike polynomials up to the 8th order within a region of 4mm in diameter. Total higher-order root mean square (defined as "-HO-RMS-"; 3rd to 8th) and RMS from the 3rd to the 8th order were calculated and compared with normal controls (age-matched 13 normal eyes). Its correlations with logarithm of minimal angle resolution (LogMAR) and DBK were evaluated.

Results: : The average pre- and postoperative LogMAR were 1.08±0.46 and 0.36 ± 0.31, respectively. The preoperative RMSs of the anterior surface, which were significantly larger than normal control, significantly decreased postoperatively. However, there was not significant difference between pre- and postoperative the RMSs of the posterior surface. The postoperative LogMAR was positively correlated with postoperative HO-RMS and 3rd-order RMS of the anterior surface (P=0.0005 and 0.0011, respectively). The preoperative RMSs of the anterior surface were not significantly correlated with postoperative LogMAR and DBK (P>0.05). The pre- and postoperative RMSs of the posterior surface had no correlation with postoperative LogMAR and DBK (P>0.05).

Conclusions: : Preoperative irregularity of the anterior surface, which decreased after DSEK, may have no impact on postoperative visual acuity. The postoperative irregularity of the anterior surface was correlated with postoperative visual acuity. The irregularity of the posterior surface did not influence the postoperative visual acuity.

Keywords: cornea: clinical science • aberrations • transplantation 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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