April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
Long-Term Outcomes of Corneal Transplantation
Author Affiliations & Notes
  • H. B. Sellevoll
    Ninewells Hospital, Dundee, United Kingdom
  • W. J. Armitage
    Academic Unit of Ophthalmology, University of Bristol, Bristol, United Kingdom
  • M. S. Figueiredo
    Department of Ophtalmology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
  • R. S. M. Figueiredo
    Ninewells Hospital, Dundee, United Kingdom
  • F. C. Figueiredo
    Department of Ophtalmology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
  • Footnotes
    Commercial Relationships  H.B. Sellevoll, None; W.J. Armitage, None; M.S. Figueiredo, None; R.S.M. Figueiredo, None; F.C. Figueiredo, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 2200. doi:
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      H. B. Sellevoll, W. J. Armitage, M. S. Figueiredo, R. S. M. Figueiredo, F. C. Figueiredo; Long-Term Outcomes of Corneal Transplantation. Invest. Ophthalmol. Vis. Sci. 2009;50(13):2200.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate the clinical outcomes of penetrating keratoplasty patients in a single tertiary centre in the United Kingdom (UK). The Newcastle Corneal Transplant Registry (NCTR) is an 11-year prospective study.

Methods: : The NCTR is a prospective, single-centre, noncomparative, interventional case series of 529 consecutive corneal transplants by one surgeon.

Results: : Mean follow-up was 55 months (range 10-125 months). 142 patients were male with a mean age of 59 years (SD 21, range 7-93). 225 transplants were entered at the start of the 5-year follow-up period: 17 failed at 5 years, but no failures were seen in the keratoconus, Fuchs’ or infections groups. Five-year survival was 79% (95% CI 62, 96) for bullous keratopathy, 73% (95% CI 56, 90) for regrafts, and 56% (95% CI 22, 90) for ‘other’ indications. Survival was influenced by indication (p<0.0001). Mean donor ECD was 2616 cells/mm² (SD 250). ECD fell to 898 cells/mm² (SD 470) by 5 years, giving an overall cell loss of 66% (SD 18), ranging from 61% (SD 21) for keratoconus to 75% (SD 15) for bullous keratopathy and 75% (SD 9) for regrafts. Indication had no influence on cell loss (p=0.25).

Conclusions: : Corneal graft survival was influenced by indication and our data demonstrated survival at 5 years comparable to other studies. The endothelial cell loss at 5 years demonstrates continued endothelial instability/dysfunction that may result in late graft failure. Original pathology does not influence endothelial cell loss postoperatively. The NCTR offers a unique opportunity to analyse the long-term outcomes of corneal transplantation in a UK ophthalmic unit and to guide clinical practice.

Keywords: cornea: clinical science • transplantation • cornea: endothelium 

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