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F. Bertuzzi, S. Bochicchio, F. Verga, R. Angeli, M. Suzani, E. Rulli, S. Miglior; Intraobserver and Interobserver Reproducibility in the Evaluation of Optic Disc and Retinal Nerve Fiber Layer by Rtvue Fourier-Domain Optovue. Invest. Ophthalmol. Vis. Sci. 2009;50(13):2262.
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© ARVO (1962-2015); The Authors (2016-present)
To assess intraobserver and interobserver reproducibility of morphometric measurements on optic disc and retinal nerve fiber layer in glaucoma (POAG), ocular hypertensive(OHT) and normal subjects by means of RTVue Fourier-Domain OCT. Study
ICC showed worst scores on rim (0.02 to 0.48) and nerve head (-0.01 to 0.17)volume in all of the calculations. Best scores were found on RNFL related parameters (0.94 to 1),either on intraobserver-interimage or interobserver-intra/interimage evaluations. The CL drawing system did not affect reproducibility of these parameters. The parameters cup-disc horizontal and vertical ratio showed substantial to very good correlation (0.67 to 0.88) both in intra- and interoperator evaluation, except when the 3D baseline CL was used. In general, in all of the evaluations, the 3D baseline CL drawing had worse scores than OCT and video-baseline drawing systems. Interimage (33.3 to 47,2% parameters ICC > 0.7) showed a higher variability than intraimage (50% parameters ICC > 0.7) evaluation.
Measurement of RNFL parameters by means of RTVue is highly reproducible and slightly operator-dependent. Optic nerve head measurements are less reproducible and more operator-dependent than RNFL values. 3D baseline showed higher variability than OCT and video-baseline. Since the intra-image comparison gives the best ICC scores, image acquisition is more a source of variability than contour line drawing.
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