April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Vascular Endothelial Growth Factor Level in Aqueous Humor of Eyes With Myopic Choroidal Neovascularization
Author Affiliations & Notes
  • O. Sawada
    Ophthalmology, Shiga Univ of Medical Science, Otsu, Japan
  • H. Kawamura
    Ophthalmology, Shiga Univ of Medical Science, Otsu, Japan
  • M. Kakinoki
    Ophthalmology, Shiga Univ of Medical Science, Otsu, Japan
  • T. Sawada
    Ophthalmology, Shiga Univ of Medical Science, Otsu, Japan
  • M. Ohji
    Ophthalmology, Shiga Univ of Medical Science, Otsu, Japan
  • Footnotes
    Commercial Relationships  O. Sawada, None; H. Kawamura, None; M. Kakinoki, None; T. Sawada, None; M. Ohji, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 2284. doi:
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      O. Sawada, H. Kawamura, M. Kakinoki, T. Sawada, M. Ohji; Vascular Endothelial Growth Factor Level in Aqueous Humor of Eyes With Myopic Choroidal Neovascularization. Invest. Ophthalmol. Vis. Sci. 2009;50(13):2284.

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Abstract

Purpose: : To study the level of vascular endothelial growth factor (VEGF) in the aqueous humor of eyes with myopic choroidal neovascularization (mCNV).

Methods: : Aqueous humor samples were obtained from 21 eyes of 21 patients with mCNV before intravitreal injection of bevacizumab. Aqueous humor samples also were obtained just before cataract surgery in 13 patients with cataract without other ocular or systemic diseases (control group). The VEGF concentration in the aqueous humor was measured using an enzyme-linked immunosorbent assay.

Results: : The VEGF concentrations in the aqueous humor of eyes with mCNV ranged from less than 20 to 200 pg/mL (median, 35 pg/mL). The concentrations in the control group ranged from 76 to 218 pg/mL (median, 148 pg/mL). The VEGF concentration in the aqueous humor was significantly lower in patients with mCNV than that in the control group (t- test, P < 0.001).

Conclusions: : In patients with mCNV, the VEGF concentration in the aqueous humor is lower than in the control group. VEGF might localize in or around the CNV in eyes with mCNV.

Keywords: vascular endothelial growth factor • aqueous • myopia 
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