Abstract
Results: :
I- Treatment with pilocarpine in all concentrations greater than 0.5% had a highly significant lowering effect on IOP when compared with no treatment. Two groups were identified, those with and those without a significant IOP decrease. Pilocarpine concentration up to 8% did not lower IOP in the unresponsive group.II- Four times daily administration resulted in significantly lower IOP than daily or twice daily. Twice daily treatment was slightly more effective than daily treatment. A single daily dose caused a lowering of IOP of about 4 mmHg that lasted over 24 hours. Fifty nine hours after the last dose there was no evident effect.
Clinical Trial: :
www.clinicaltrials.gov NTC00798700
Keywords: intraocular pressure • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • drug toxicity/drug effects