Purchase this article with an account.
A. Usui, A. Mizota, O. Miyauchi, I. Takahashi, M. Tanaka; Twenty-Four Hour Intraocular Pressure With Dorzolamide Added to Latanoprost in Primary Open-Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2009;50(13):2484.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To study the effect of dorzolamide added to latanoprost monotherapy to the 24-hour intraocular pressure change in primary open-angle glaucoma patients.
Patients who were treated with latanoprost monotherapy and had intraocular pressure controlled under 21mmHg were enrolled in the present study. To know the baseline 24-hour variation of intraocular pressure with latanoprost monotherapy after the use of latanoprost for more than 4 weeks once daily at 8 o’clock in the morning, intraocular pressure was measured at 1, 3, 7, 10, 13, 16, 19, 23 o’clock. Four weeks after adding dorzolamide three times daily at 8, 14 and 21 o’clock, 24-hour variation of intraocular pressure was evaluated with same time schedule. This study was approved ethical committee in Juntendo University Urayasu Hospital. Repeated measure analysis of variance and Wilcoxon signed-rank test were used for statistical analysis.
In the comparison of 24-hour variation of intraocular pressure before and after adding dorzolamide, intraocular pressures were significantly reduced at 1, 3, 7, 16, 19 and 23 o’clock. The reduction of intraocular pressure was greater in midnight (1, 3, 23 o’clock) than in daytime. In the comparison of the 24-hour mean intraocular pressure before and after adding dorzolamide, the mean of 24-hour intraocular pressure reduced by 1.4mmHg and the percent reduction of the mean of 24-hour intraocular pressure was 10.6%.
This study suggests that dorzolamide added to latanoprost lower intraocular pressure at all measurement time point, and especially the reduction was greater at night than during the day.
This PDF is available to Subscribers Only