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X.-H. Sun, M. Xiao, W.-Y. Guo, S.-H. Qian, F.-R. Meng; Evaluation of Anti-Glaucoma Drops for 24 Hours Intraocular Pressure Control. Invest. Ophthalmol. Vis. Sci. 2009;50(13):2487.
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To evaluation the effects of anti-glaucoma drops in the Chinese POAG cases with large IOP fluctuation.
Fifty-two cases with the normal diurnal IOP range by anti-glaucoma drops likeβ-blockers, -agonists and topical CAIs but still with glaucomatous progression were enrolled. With continuous original anti-glaucoma drops, all these cases have been measured 24 hrs IOP by NCT per 2 hours at time points as 8:00, 10:00, 12:00, 14:00, 16:00, 18:00, 20:00, 22:00, 24:00, 2:00, 4:00 and 6:00 at seat. And then after shifting to prostaglandins drops at least one month late, 24 hrs IOP measurements every two hours were repeated.
The peaks of 24 hrs IOP curve were during 24:00~6:00 with 70.8% cases and during 2:00~4:00 with 49.3% cases, which were treated by anti-glaucoma drops likeβ-blockers, -agonists and topical CAIs. There were 34 (32.7%) eyes with IOP fluctuation ≥8mmHg and 71 (68.3%) eyes with IOP fluctuation ≥5mmHg. After shifting to prostaglandins drops there were a decrease with IOP fluctuation as 15.4% eyes ≥8mmHg and 30.8% eyes ≥5mmHg.
The peaks of 24 hrs IOP of these cases were mostly during the midnight to the early morning. Prostaglandins drops are better for controlling the peak and the fluctuation then that β-blockers, -agonists and topical CAIs in these glaucoma cases.
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