Purchase this article with an account.
J. H. Kim, T. S. Prata, V. C. Lima, C. G. V. DeMoreas, S. Dorairaj, W. Seiple, R. Rosen, J. M. Liebmann, R. Ritch; A Comparison Between Microperimetry and Standard Achromatic Perimetry in Glaucomatous Patients With Central Scotomas. Invest. Ophthalmol. Vis. Sci. 2009;50(13):2535.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
We evaluated retinal sensitivity using microperimetry in glaucomatous eyes with central visual field loss detected by achromatic standard automated perimetry (SAP), and correlated microperimetry with SAP results.
We included 20 eyes of 14 patients with glaucomatous optic neuropathy and central (10°) visual field loss. Eyes with other diseases that could affect the central visual field were excluded. All patients underwent microperimetry (Opko/OTI, Toronto, Canada; Humphrey 10-2 pattern) and SAP (SITA-Standard 10-2) within 2 months. Results for each eye were divided into 4 quadrants for analysis. Linear regression was used to correlate the mean values of microperimetry thresholds (dB) and SAP thresholds (dB) in each quadrant. Normal and abnormal quadrants by SAP were compared to the corresponding quadrants using microperimetry, and macular thickness data (Stratus OCT) was used in cases of disagreement.
Mean age and MD were 60.8±13.4 years and -7.3±6.1 dB, respectively. There was a strong correlation between microperimetry and SAP results in all quadrants (inferior temporal quadrant, r2=0.85; IN, r2=0.72; SN, r2=0.65; ST, r2=0.64; p<0.01). All abnormal SAP quadrants (depression of at least 10 dB at one point or of 5 dB in ≥ 2 contiguous points) had a corresponding abnormal microperimetry quadrant (depression of at least 10 dB in one point or of 8 dB in ≥2 contiguous points). However, 21% (8/38) of the normal SAP quadrants had an abnormal corresponding microperimetry result (6 eyes); a corresponding OCT abnormality was present in 72% of these quadrants.
Retinal sensitivity evaluated by microperimetry correlated strongly with SAP results in glaucomatous patients with central scotomas. Microperimetry detected retinal sensitivity reduction in areas of structural damage with normal SAP and suggests that microperimetry can be used as a more sensitive tool to detect visual function loss in glaucomatous eyes.
This PDF is available to Subscribers Only