April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
Longitudinal Change in Mood Indicators in the Collaborative Initial Glaucoma Treatment Study (CIGTS)
Author Affiliations & Notes
  • H. D. Jampel
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • K. D. Frick
    Health Policy and Management, Bloomberg School of Public Health of Johns Hopkins University, Baltimore, Maryland
  • N. K. Janz
    Department of Health Behavior and Health Education, University of Michigan School of Public Health, Ann Arbor, Michigan
  • D. C. Musch
    Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan
  • Collaborative Initial Glaucoma Treatment Study
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland
  • Footnotes
    Commercial Relationships  H.D. Jampel, None; K.D. Frick, None; N.K. Janz, None; D.C. Musch, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 2569. doi:
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      H. D. Jampel, K. D. Frick, N. K. Janz, D. C. Musch, Collaborative Initial Glaucoma Treatment Study; Longitudinal Change in Mood Indicators in the Collaborative Initial Glaucoma Treatment Study (CIGTS). Invest. Ophthalmol. Vis. Sci. 2009;50(13):2569.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To assess the relationship of changes over time in visual acuity (VA), visual field (VF), and subjects’ report of problems performing visual activities, with changes in symptoms of depression among subjects in the CIGTS.

Methods: : Subjects in the CIGTS had newly diagnosed untreated open angle glaucoma. Subjects were examined (VA and VF) and surveyed prior to treatment and every six months afterwards. A first-difference regression was used to analyze the relationships among changes from one time to the next. The dependent variables in the regressions were the changes in the Center for Epidemiological Studies Depression Scale (CESD) score or changes in responses to particular CESD questions. Independent variables included changes in better and worse VA, better and worse VF, the Visual Activities Questionnaire (VAQ), as well as baseline values of each, and age, sex, and time interval.

Results: : Changes in the VAQ and the VF score in the better eye over time were correlated (coefficients of 1.28 & 0.12, p < .0001 & p = 0.0017, respectively) with change in the total CESD score. Change in VAQ score was a predictor of a change from a "no" response to a "yes" response to questions on the CESD concerning the presence of nervousness, anxiety, or stress; fatigue or lack of energy; depression; and frequent mood swings (ORs ranging from 1.7 to 2.5, p < 0.0001) whereas neither change in VA or VF in either eye was a predictor.

Conclusions: : Changes in depression in this cohort of treated glaucoma subjects are strongly correlated with changes in patient reported difficulty in performing vision-related tasks and weakly associated with changes in VF in the better seeing eye. These longitudinal findings provide stronger evidence than our cross-sectional study (Am J Ophthalmology 2007; 144:238-244.) for the close link between patient perception of visual difficulties and mood.

Keywords: quality of life • clinical (human) or epidemiologic studies: outcomes/complications 

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