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H. Mino de Kaspar, M. Rajab, L. He, Y. Yactayo-Miranda, M. M. Nentwich, A. Gandorfer, C. Haritoglou, M. Grueterich, A. Kampik; Efficacy of 10% Povidone Iodine Application in Reducing the Conjunctival Bacterial Load of Patients Undergoing Cataract Surgery. Invest. Ophthalmol. Vis. Sci. 2009;50(13):2899.
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To determine the efficacy of 10% povidone iodine (PVI) drops in the reduction of conjunctival load, given before cataract extraction.
In this prospective study on in- and out-patients undergoing cataract surgery, participants were randomized into Group 1 (standard pretreatment with 1% PVI irrigation) and Group 2 (additional pretreatment with 10% PVI eye-drops) after consent and according to the protocol approved by the Institutional Review Board. All 70 outpatients received neomycin eye drops the hour before surgery while all 91 in-patients received four times one drop of neomycin the day prior to the intervention. During preoperative preparation, all eyes were first disinfected periorbitally with 10% PVI. In Group 1 eyes were irrigated subsequently with 10mL of 1% PVI just before surgery, while in Group 2 patients were given (in addition to the treatment of Group 1) 3 drops of 10% PVI 10 minutes before surgery. Conjunctival specimens were collected and inoculated in thioglycolate broth at the following time-points: T1 - upon arrival in the operate room, T2 - after 1% PVI irrigation, before surgery, T3 - post-surgery. All culture growth was identified and the results compared between groups (see tables).
The addition of 3 drops of 10% PVI before surgery to a prophylactic regime consisting of antibiotic application and irrigation with 10 mL of 1% PVI did not result in significant additional benefits in the reduction of conjunctival bacterial load in both in- and out-patients.
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