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T. H. Cronin, R. W. Hertle, H. Ishikawa, J. S. Schuman; Spectral Domain Optical Coherence Tomography in the Oculocutaneous Albino Population. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3042.
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To evaluate the clinical utility of spectral domain optical coherence tomography (SD-OCT) on macular imaging in eyes with oculocutaneous albinism (OCA) and to investigate the afferent and efferent system in this unique subset of nystagmus patients using SD-OCT.
Three-dimensional macular cube scans (200x200x1024 samplings in a 6x6 mm region centered on fovea) were obtained 3 times on each eye of 9 OCA patients. The central macular thickness and horizontal eye movement frequency were recorded. The average horizontal eye movement frequency was compared to that obtained from eye movement recordings.
The age range of the 9 patients was 7-58 years (average 18 years). All patients had infantile nystagmus syndrome (INS) with 6 patients (67%) displaying aperiodicity. Macular images were successfully obtained in 8 patients (89%). Seven patients (88%) demonstrated "fovea plana" and one patient demonstrated a slight foveal depression. In agreement with prior studies, central macular thickness was found to be increased in the OCA population (284µm ± 56µm) compared to the general population. Eye movement frequency on SD-OCT (range 2-4 Hz, average 3.5 ± 0.8 Hz) was calculated and agreed with that of eye movement recordings (range 2-5 Hz, average 3.6 ± 0.6 Hz, paired student t-test, 95% CI [-0.7,0.5], p = 0.78).
SD-OCT provides detailed structural imaging of the sensory system of OCA despite perpetual eye movement during scanning, revealing a major structural anomaly in the macula. In addition, SD-OCT offers an alternative method of studying the motor physiology of ocular oscillation in OCA.Figure 1. Frame from SD-OCT movie demonstrating fovea plana in oculocutaneous albino eye with infantile nystagmus syndrome at 3-5 Hz frequency.Figure 2. SD-OCT image of y-plane demonstrating horizontal nystagmus eye movements at 3-5 Hz frequency.
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