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S. Schroeder, A. Caramoy, P. Muether, M. Abdel-Salam, M. Diestelhorst, B. Kirchhof, S. Fauser; Quantification of Changes in the Ocular Barrier Function in Eyes With Retinal Detachment by Laser Flare Cell Meter. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3162.
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© ARVO (1962-2015); The Authors (2016-present)
Aim of this study was to determine whether aqueous flare measured with Laser Flare Cell Meter (LFCM) can be used as a prognostic tool to detect ocular barrier breakdown in eyes with retinal detachment. LFCM is tested as a tool to predict the risk of Proliferative Vitreoretinopathy (PVR).
We report on 87 eyes with retinal detachment. All patients received a detailed ophthalmic examination in our clinic. This examination was also concurrently performed on 88 normal eyes. Aqueous flare was evaluated using the FC-500 LFCM (version 1.0) (Kowa Company Ltd, Tokyo, Japan). From each eye five measurements were taken and averaged. Flare values were expressed as photon counts/ms (pc/ms). Results were given as mean ± standard deviation and were analyzed using software of SPSS 15.0. The statistical methods used in this study included Explorative Data Analysis and Mann-Whitney-U-Test.
In eyes with retinal detachment aqueous flare ranged from 0.04 to 178.00 (pc/ms) (mean 19.32 ± 26.70) and was significantly increased in comparison to the control group (mean 6.09 ± 5.56, range 0.06 - 46.78 pc/ms, p<0.0001).Flare values in pseudophakic eyes with retinal detachment (33.52 ± 75.31, range 5.08 - 127.6) were significantly higher than in phakic eyes with retinal detachment (13.85 ± 14.48, range 2.62 - 85.20 pc/ms, p<0.0001).
The results of our study clearly indicate that aqueous protein concentration, as determined by aqueous flare, is significantly increased in eyes with retinal detachment in comparison to the control group. Flare values in pseudophakic eyes with retinal detachment were significantly higher than in phakic eyes with retinal detachment. A significant increase of flare values indicates the breakdown of the blood retina barrier in eyes suffering from retinal detachment. Measurements with LFCM may be a useful non-invasive tool to quantify changes of the ocular barrier functions. None of our patients has developed PVR. Larger patient numbers are required to evaluate LFCM as a tool to screen patients at risk of PVR.
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