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I. Pereira, S. Nunes, L. Ribeiro, L. Duarte, A. Santos, R. Bernardes, J. Cunha-Vaz; Weak Correlation Between Retinal Thickness and BCVA in CSME Eyes of Patients With Diabetes Type 2. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3245.
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To investigate the correlation between retinal thickness using high definition OCT (Cirrus OCT) and best-corrected visual acuity (BCVA) in eyes with clinically significant macular edema (CSME) in patients with diabetes type 2.
Retinal thickness was measured with the Stratus OCT and the spectral domain high-definition Cirrus OCT. For the Stratus OCT, two measures were considered, the central point thickness and the 1000-µm diameter area. For the Cirrus OCT, the values considered were the 500- and the 1000-µm diameter areas. Eyes were classified as having or not having central foveal involvement by both stereocolor fundus photography and Stratus OCT central point thickness measurements.
Only moderate correlations were found between retinal thickness and BCVA values (|R| ranging from 0.479 to 0.537; p<0.05), although eyes with central foveal involvement showed higher correlations compared to eyes without central foveal involvement. A robust correlation was found only in 50% of the eyes. The increased resolution of Cirrus OCT allowed for a better separation of eyes without central foveal involvement showing clearly, in these eyes, no correlation between retinal thickness and BCVA (|R| ranging from 0.005 to 0.116; p>0.05).
Values in the correlation between retinal thickness and BCVA vary widely in diabetic retinal edema, with only 50% of cases showing a robust correlation, indicating that OCT thickness measurements cannot be used as a surrogate for visual acuity changes.
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