April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Peripapillary Retinal Nerve Fiber Layer Thickness Measurement by Spectral Domain Optical Coherence Tomography, Scanning Laser Polarimetry and Confocal Scanning Laser Ophthalmoscopy in Normal Subjects
H. Saito; A. Tomidokoro; M. Araie; M. Hangai; S. Ohkubo; M. Shirakashi; K. Sugiyama; A. Iwase; H. Abe; N. Yoshimura
Author Affiliations & Notes
  • H. Saito
    Ophthalmology, Tajimi Municipal Hospital, Tajimi, Japan
    Ophthalmology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
  • A. Tomidokoro
    Ophthalmology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
  • M. Araie
    Ophthalmology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
  • M. Hangai
    Ophthalmology and visual sciences, Kyoto University, Graduate School of Medicine, Kyoto, Japan
  • S. Ohkubo
    Ophthalmology and visual science, Kanazawa University, Graduate School of Medical Science, Kanazawa, Japan
  • M. Shirakashi
    Ophthalmology and visual sciences, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan
  • K. Sugiyama
    Ophthalmology and visual science, Kanazawa University, Graduate School of Medical Science, Kanazawa, Japan
  • A. Iwase
    Ophthalmology, Tajimi Municipal Hospital, Tajimi, Japan
  • H. Abe
    Ophthalmology and visual sciences, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan
  • N. Yoshimura
    Ophthalmology and visual sciences, Kyoto University, Graduate School of Medicine, Kyoto, Japan
  • Footnotes
    Commercial Relationships  H. Saito, Topcon, F; A. Tomidokoro, Topcon, F; M. Araie, Topcon, C; M. Hangai, Topcon, F; S. Ohkubo, Topcon, F; M. Shirakashi, Topcon, F; K. Sugiyama, Topcon, C; A. Iwase, Topcon, C; H. Abe, Topcon, C; N. Yoshimura, Topcon, C.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 3254. doi:
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      H. Saito, A. Tomidokoro, M. Araie, M. Hangai, S. Ohkubo, M. Shirakashi, K. Sugiyama, A. Iwase, H. Abe, N. Yoshimura; Peripapillary Retinal Nerve Fiber Layer Thickness Measurement by Spectral Domain Optical Coherence Tomography, Scanning Laser Polarimetry and Confocal Scanning Laser Ophthalmoscopy in Normal Subjects. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3254.

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Abstract

Purpose: : To compare average peripapillary retinal nerve fiber layer thickness (avg RNFLT) determined by spectral domain optical coherence tomography (SD-OCT, 3D-OCT1000), scanning laser polarimetry (GDx with variable corneal compensation [VCC] and enhanced corneal compensation [ECC]) and confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomography [HRT] II).

Methods: : In 164 eyes of 164 normal subjects, avg RNFLT was determined with SD-OCT, GDx VCC/ECC, and HRT II, and was correlated with each other. The peripapillary area was divided into 6 sectors for regional analysis.

Results: : Subjects’ age averaged 51.1±16.2 (range: 21~77) years old and spherical equivalent error (SE) -0.63±1.64 (-5.75~2.88) diopters (D). In 135 eyes of 135 subjects with reliable SD-OCT and GDx results, avg RNFLT by SD-OCT at a 3.4mm diameter significantly correlated with the TSNIT average of GDx VCC (Rs=0.48, P<0.0001) Avg RNFLT of each sector significantly correlated between the two devices (Rs=0.35~0.54, P<0.0001), although the ratio of measurement values (TSNIT average [GDx VCC]/ avg RNFLT [SD-OCT]) varied significantly among the sectors (0.40~0.69, P<0.0001). The results were similar regarding correlation between SD-OCT and GDx ECC. When the subjects were divided into half by an SE of -0.5D, there was no significant difference in correlation in avg RNFLT by SD-OCT and GDx VCC/ECC between the two groups. However, avg RNFLT by SD-OCT did not significantly correlate with those by GDx in the temporal superior and inferior sectors in myopic eyes (SE≤-0.5D), whereas significant correlation was seen in all sectors in non-myopic eyes. In 164 eyes of 164 subjects with reliable SD-OCT and HRT II results, avg RNFLT by SD-OCT did not significantly correlate with the mean RNFLT by HRT II (Rs=0.16, P=0.08).

Conclusions: : RNFLT measurements by SD-OCT and GDx VCC/ECC significantly correlated with each other in normal subjects. However, the degree of correlation was not high enough and RNFLT values were not interchangeable. No significant correlation was seen between RNFLT measured by SD-OCT and HRT II.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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