April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Microaneurysms Formation Rate as a Predictor of DR Progression to CSME Needing Photocoagulation in Nonproliferative Retinopathy in Diabetes Type 2
I. Pires; L. Duarte; S. Nunes; I. Pereira; R. Bernardes; J. Cunha-Vaz
Author Affiliations & Notes
  • I. Pires
    Coimbra University Hospital, Coimbra, Portugal
    Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal
  • L. Duarte
    Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal
  • S. Nunes
    Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal
  • I. Pereira
    Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal
  • R. Bernardes
    Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal
    Institute of Biophysics and Biomathematics,
    Institute of Biomedical Research on Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  • J. Cunha-Vaz
    Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal
    Center of Ophthalmology,
    Institute of Biomedical Research on Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  • Footnotes
    Commercial Relationships  I. Pires, None; L. Duarte, None; S. Nunes, None; I. Pereira, None; R. Bernardes, None; J. Cunha-Vaz, None.
  • Footnotes
    Support  PTDC/SAU-OSM/72635/2006
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 3270. doi:
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      I. Pires, L. Duarte, S. Nunes, I. Pereira, R. Bernardes, J. Cunha-Vaz; Microaneurysms Formation Rate as a Predictor of DR Progression to CSME Needing Photocoagulation in Nonproliferative Retinopathy in Diabetes Type 2. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3270.

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Abstract

Purpose: : To examine the relation between microaneurysms (MA) formation rate using a new semi-automatic method based on color-fundus photographs, and DR progression to clinically significant macular edema (CSME) needing photocoagulation in a 10-years follow-up period of type 2 diabetic patients with nonproliferative retinopathy.

Methods: : Seventy-seven patients/eyes with type 2 diabetes and nonproliferative retinopathy were followed-up for 2 years as controls of diabetic retinopathy clinical trials and underwent ophthalmological examinations every 6 months, including stereoscopic color fundus photography and were maintained under good metabolic control. All patients were followed-up for the next 8 years by conventional general and ophthalmological care accomplishing a total follow-up of 10 years. Photocoagulation for CSME was performed according to well defined guidelines and was considered the study main end-point. Using a new semi-automatic method for MA earmarking, which takes into account the exact location of each MA, the MA formation rate for the 2 first years of follow-up was computed (number of new MA appearing per year).

Results: : At the end of the 10-year period of follow-up, 12 of the 77 patients had developed CSME needing photocoagulation.A MA formation rate of 8.0±10.0 MA/year (Mean±SD) was found in these 12 patients’ eyes, being it statistically higher than for patients’ eyes that did not develop CSME (mean±SD: 1.8± 2.3) (p=0.003). The CSME patients presented also a higher HbA1C level at baseline (mean±SD: 8.1±1.1) compared to the remaining patients (mean±SD: 7.2±0.9; p=0.034).

Conclusions: : A high MA formation rate earmarked on color-fundus photographs appears to be a good predictor of DR progression to CSME needing photocoagulation in type 2 diabetic patients with nonproliferative retinopathy.

Keywords: diabetic retinopathy • imaging/image analysis: clinical • retina 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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