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C. Friedburg, J. Hartl, J. Schmeisser, M. N. Preising, B. Lorenz; Correlation and Age-Trends Of OCT, ERG and Visual Fields in Patients With Confirmed X-Linked Retinoschisis (XLRS). Invest. Ophthalmol. Vis. Sci. 2009;50(13):3275.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the correlations of structural retinal damage (cystic space) with the electrical (ERG) and psychophysical function (visual field) and to search for trends with age.
Retrospective analysis of 14 genetically confirmed XLRS patients aged 7 to 23 years with Goldmann visual fields, Stratus OCT 3 and Ganzfeld-ERG (DTL-electrodes, Nicolet Spirit, ISCEV standard). Retinal structure approx. 1 mm peripheral from the fovea was analysed quantitatively using OCT 3 and image processing. Structural damage was evaluated by the mean ratio of cystic to normal retinal area as obtained from 6 OCT scans in star pattern centered on the fovea and disregarding the central third. Visual field area was calculated from the coordinates of detection of I/4e targets. Electrical function was obtained by measuring b-wave and a-wave amplitude elicited by scotopic standard flashes.
Cysts occupied 10% to 40% of the retinal area in OCT without an obvious age-trend. Visual field area ranged from ~15% to normal , typically showing smaller fields for younger patients. Scotopic ERG b-waves measured between about 15% and normal values, scotopic a-waves 25% to 200% of normal and the b/a-ratio ranged from 0.7 to 1.9. Whereas absolute ERG amplitudes showed no clear trend, the b/a-ratio decreased with subject’s age. The ratio of cysts to retina showed a weak inverse correlation with visual field area but neither with b-wave nor b/a-ratio. No correlation was found between visual field and the above ERG parameters.
Although using a simplified approach, we were able to show some link of the amount of cystic retinal changes in XLRS with light sensitivity as measured by visual field with I/4e. It was difficult however, to link either of the two parameters with ERG b-wave or b/a-ratio possibly due to the large distribution of the latter. With age, a-waves appeared to deteriorate less than b-waves. The pathophysiological effects of the cysts still remain to be investigated.
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