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J. Gregush, F. Wang, G. Gregori, P. J. Rosenfeld, S. O’Mellan; Imaging Retinal Pigment Epithelial Detachments With Spectral Domain OCT. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3282.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the ability of the spectral-domain optical coherence tomography (SDOCT) to describe the morphology of retinal pigment epithelial detachments (PEDs) in patients with age-related macular degeneration (AMD).
SDOCT (Cirrus HD-OCT, from Carl Zeiss Meditec, Inc) system was used to obtain three-dimensional data sets covering a 6×6 mm region of the macula. The patients were scanned multiple times at each visit. Custom-designed software was used to analyze the scans, which can produce several quantitative descriptors of PED geometry in three- dimensional space, in particular PED area and volume. All analyses and scans were manually checked by a retinal specialist and an image analyzer before and after the quantification.
Twenty-three eyes of 21 patients, 5 men and 16 women, 73 years of mean age with AMD were scanned. Our automatic segmentation based software accurately demarcated the boundaries of the RPE in most cases. The area of PEDs measured in this study ranged from 0.568 to 10.116 mm2 and the volume ranged from 0.072 to 2.523 mm3.
Quantitation of PED morphology can be achieved using SD-OCT images. This approach will prove useful in documenting PED progression and response to therapy.
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