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I. Maruko, A. Ojima, T. Sekiryu, M. Saito, T. Iida; Subretinal Precipitates and Deposits in Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3284.
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Multiple yellowish dot-like ‘Precipitates’ and yellow ‘Deposits’ are sometimes observed within area of the serous retinal detachment (SRD) in central serous chorioretinopathy (CSC). We report the occurrence frequency and the clinical features of the Precipitates and Deposits in CSC.
Seventy-eight eyes of 73 patients (60 men, 13 women) with CSC from 2005 to 2007 were examined retrospectively. All eyes showed the SRD that involved the macular area on the biomicroscopy and the dye leakage from the retinal pigment epithelium (RPE) on the fluorescein angiography. Optical coherence tomography (OCT) and fundus autofluorescence were also evaluated in all cases during the follow-up period. Deposits were defined as the subretinal yellow materials with larger than 63µm in diameter.
The duration of SRD estimated from the subjective symptom was an average of 19.3 months (range 1-142 months). Forty-four eyes (56.4%) with Precipitates and 38 eyes (48.7%) with Deposits were observed redundantly, and total 50 eyes (64.1%) had either both or at least one of them. Precipitates turned into Deposits in some cases. Ten eyes (26%) with foveal deposition, 19 eyes (50%) with leopard spot like deposition, and 9 eyes (24%) with inferior edge deposition in SRD were seen in the eyes with Deposits. Forty (80%) of 50 eyes with Precipitates and Deposits showed the highly reflective materials in the outer retinal layer or on the RPE layer by OCT. Most Precipitates and Deposits demonstrated the hyperautofluorescence during the follow-up period.
Precipitates and Deposits were observed in many cases with CSC. Most cases with Precipitates and Deposits showed the highly reflection on OCT and the hyperautofluorescence. These may indicate the shedding and metabolism of photoreceptor outer segments are associated with the formation of Precipitates and Deposits.
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