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A. Abazari, S. S. Allam, N. G. Ghazi; Optical Coherence Tomography Findings in Autoimmune Retinopathy. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3288.
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To report the optical coherence tomography (OCT) findings in patients with autoimmune retinopathy.
A consecutive case series of seven patients with newly diagnosed autoimmune retinopathy was conducted. The diagnosis was based on a detailed ophthalmic exam, automated visual field testing, electroretinography, and laboratory evaluation for serum antiretinal antibodies. OCT of the macula and nerve fiber layer was performed on all of these patients and the results were reviewed. Data are presented as mean ± standard deviation. A systemic workup to evaluate for occult malignancy was performed when indicated.
Six females and one male with a mean age of 59±15 years with unexplained loss of vision, visual field defect or photopsia, were diagnosed with autoimmune retinopathy. All 7 patients tested positive for serum antiretinal antibodies. Systemic workup for occult malignancy was unremarkable. The OCT of the nerve fiber layer was normal in all patients. In contrast, macular OCT showed reduced central macular and foveal thicknesses in five patients (mean thickness 143±30 µm and 131±29 µm respectively). In the other two patients the mean central macular and foveal thickness was 244±36 and 223±36 µm respectively. There was no significant difference between the central macular and foveal thickness of the left and right eyes. In all but one patient loss of the photoreceptor layer or disruption of the photoreceptor outer and inner segment junction was noted on OCT. Interestingly, the extent of retinal atrophy on OCT did not seem to correlate with baseline visual acuity.
Outer retinal atrophy and reduced macular thickness on OCT are seen in patients with autoimmune retinopathy. OCT is useful in the evaluation of patients with unexplained visual loss and may provide diagnostic clues in patients with suspected autoimmune retinopathy.
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