April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
Diabetic Macular Edema Phenotypes: The Imaging Perspective
Author Affiliations & Notes
  • E. Midena
    Department of Ophthalmology,University of Padova, Padova, Italy
    Fondazione GB Bietti, IRCCS, Roma, Italy
  • M. Casciano
    Department of Ophthalmology,University of Padova, Padova, Italy
  • E. Bottega
    Department of Ophthalmology,University of Padova, Padova, Italy
  • E. Benetti
    Department of Ophthalmology,University of Padova, Padova, Italy
  • S. Vujosevic
    Fondazione GB Bietti, IRCCS, Roma, Italy
  • Footnotes
    Commercial Relationships  E. Midena, None; M. Casciano, None; E. Bottega, None; E. Benetti, None; S. Vujosevic, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 3297. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      E. Midena, M. Casciano, E. Bottega, E. Benetti, S. Vujosevic; Diabetic Macular Edema Phenotypes: The Imaging Perspective. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3297.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : Diabetic macular edema (DME) shows variable clinical characteristics with unpredictable results to local treatment, probably reflecting different phenotypes. The aim of this study was to evaluate the role of structural and functional macular imaging in the characterization of DME patterns.

Methods: : One hundred twenty one eyes of 75 diabetic patients with untreated DME underwent: best corrected visual acuity determination (BCVA, logMAR), slit lamp biomicroscopy, fluorescein angiography, OCT (mean central field (CF) retinal thickness, DME pattern, and spectral domain volume), fundus autofluorescence (FAF): absent or increased FAF (IFAF: single and multple spots; IFAF area quantification), retro-mode scanning laser ophthalmoscopy and microperimetry . Sensitivity values are expressed as the median of mean retinal sensitivity of each study group.

Results: : Thirty five eyes had normal FAF, 86 IFAF (28 single spot IFAF, 58 multiple spots IFAF). Retinal sensitivity over areas with IFAF was 10.5 dB (vs 15.2 db in normal areas,p<0.005). Retinal sensitivity of the CF vs FAF was: 14.6 dB normal FAF,12.10 dB single spot and 10.9 dB multiple spots IFAF(p<0.05) . A significant correlation was found between area of IFAF , positive retro-mode imaging and CF retinal sensitivity(r=-0.4,p=0.01). Cystoid OCT-pattern and macular volume were correlated to both presence and dimension of IFAF and retro-mode imaging (p<0.05), whereas sponge-like and subfoveal neuroretinal detachment were not correlated. OCT-CF thickness did not correlate to FAF pattern and retro-mode imaging (p=0.1). BCVA did not correlate either to FAF pattern or area of IFAF.

Conclusions: : The use of an integrated structural and functional retinal imaging approach allows to identify some (new) different DME phenotypes, which may be related to treatment prognosis when prospectively evaluated.

Keywords: diabetic retinopathy • edema • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.