Abstract
Purpose: :
Peripheral retinal vascular abnormalities may be detected with ultra-wide field angiography. This study seeks to determine whether the peripheral retinal vascular abnormalities of capillary non-perfusion and late peripheral vessel leakage (LPVL) correlate with other findings in central retinal vein occlusion (CRVO), including macular ischemia, neovascularization, and macular edema.
Methods: :
In a retrospective, consecutive case series, ultra wide-field angiographs obtained at a single institution were reviewed by a single grader for angiographic characteristics relevant to CRVO. Statistical analyses used the Fisher exact test.
Results: :
Angiographic characteristics of 44 eyes were evaluated. Features included macular ischemia (27%), cystoid macular edema (82%), neovascularization (7%), LPVL (70%), and peripheral non-perfusion (55%). Macular edema was related to LPVL (30/36 [83%] vs. 1/8 [13%], p<0.001), but was not related to macular ischemia (p=0.663) or peripheral non-perfusion (p=1.00). Peripheral non-perfusion was significantly related to macular ischemia (10/12 [83%] vs. 14/32 [44%]; p=0.039), and weakly related to LPVL (20/31 [65%] vs. 4/13 [31%]; p=0.053). There was no relationship between macular ischemia and LPVL (p=0.459). After excluding eyes with PRP (n=13), peripheral non-perfusion was associated with LPVL (p=0.050).
Keywords: retina • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • macula/fovea