April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
Peripheral Vessel Leakage and Capillary Non-Perfusion - The Ischemic Index in Central Retinal Vein Occlusion?
Author Affiliations & Notes
  • S. C. Oliver
    Ophthalmology, University of Colorado Denver, Aurora, Colorado
  • R. E. Coffee
    Ophthalmology, UCLA, Los Angeles, California
  • S. D. Schwartz
    Ophthalmology, UCLA, Los Angeles, California
  • Footnotes
    Commercial Relationships  S.C. Oliver, Optos plc, C; Optos plc, R; R.E. Coffee, None; S.D. Schwartz, Optos plc, C; Optos plc, R.
  • Footnotes
    Support  Frederick G. Rappaport Fellowship to Scott C. Oliver, MD
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 3315. doi:
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      S. C. Oliver, R. E. Coffee, S. D. Schwartz; Peripheral Vessel Leakage and Capillary Non-Perfusion - The Ischemic Index in Central Retinal Vein Occlusion?. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3315.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : Peripheral retinal vascular abnormalities may be detected with ultra-wide field angiography. This study seeks to determine whether the peripheral retinal vascular abnormalities of capillary non-perfusion and late peripheral vessel leakage (LPVL) correlate with other findings in central retinal vein occlusion (CRVO), including macular ischemia, neovascularization, and macular edema.

Methods: : In a retrospective, consecutive case series, ultra wide-field angiographs obtained at a single institution were reviewed by a single grader for angiographic characteristics relevant to CRVO. Statistical analyses used the Fisher exact test.

Results: : Angiographic characteristics of 44 eyes were evaluated. Features included macular ischemia (27%), cystoid macular edema (82%), neovascularization (7%), LPVL (70%), and peripheral non-perfusion (55%). Macular edema was related to LPVL (30/36 [83%] vs. 1/8 [13%], p<0.001), but was not related to macular ischemia (p=0.663) or peripheral non-perfusion (p=1.00). Peripheral non-perfusion was significantly related to macular ischemia (10/12 [83%] vs. 14/32 [44%]; p=0.039), and weakly related to LPVL (20/31 [65%] vs. 4/13 [31%]; p=0.053). There was no relationship between macular ischemia and LPVL (p=0.459). After excluding eyes with PRP (n=13), peripheral non-perfusion was associated with LPVL (p=0.050).

Keywords: retina • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • macula/fovea 

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