April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Local Retinal Ganglion Cell Thickness Can Be Measured in Patients With Glaucoma Using Frequency-Domain Optical Coherence Tomography
Author Affiliations & Notes
  • M. Wang
    Psychology, Ophthalmology,
    Columbia University, New York, New York
    Ophthalmology and Visual Sciences, Eye and Ear Nose Throat Hospital, Shanghai Medical School, Fudan University, Shanghai, China
  • D. C. Hood
    Psychology and Ophthalmology, Einhorn Clinical Research Center,
    Columbia University, New York, New York
  • J.-S. Cho
    Psychology, Ophthalmology,
    Columbia University, New York, New York
  • Q. Ghadiali
    Psychology, Ophthalmology,
    Columbia University, New York, New York
  • G. V. De Moraes
    Psychology, Ophthalmology,
    New York Eye and Ear Infirmary, New York, New York
  • X. Zhang
    Psychology, Ophthalmology,
    Columbia University, New York, New York
  • V. C. Greenstein
    Ophthalmology,
    Columbia University, New York, New York
  • R. Ritch
    Psychology and Ophthalmology, Einhorn Clinical Research Center,
    New York Eye and Ear Infirmary, New York, New York
  • J. M. Liebmann
    Psychology and Ophthalmology, Einhorn Clinical Research Center,
    New York Eye and Ear Infirmary, New York, New York
  • Footnotes
    Commercial Relationships  M. Wang, None; D.C. Hood, Topcon Inc., C; J.-S. Cho, None; Q. Ghadiali, None; G.V. De Moraes, None; X. Zhang, None; V.C. Greenstein, None; R. Ritch, None; J.M. Liebmann, Topcon Inc., C.
  • Footnotes
    Support  NIH Grant EY09076 and EY02115, Shelley and Steven Einhorn Research Fund
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 3321. doi:
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      M. Wang, D. C. Hood, J.-S. Cho, Q. Ghadiali, G. V. De Moraes, X. Zhang, V. C. Greenstein, R. Ritch, J. M. Liebmann; Local Retinal Ganglion Cell Thickness Can Be Measured in Patients With Glaucoma Using Frequency-Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3321.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To explore the feasibility of obtaining a local measure of the thickness of the retinal ganglion cell (RGC) layer in patients with glaucoma using frequency-domain optical coherence tomography (fdOCT) and a computer-aided manual segmentation procedure.

Methods: : FdOCT scans were obtained from the horizontal midline for one eye of 26 patients with glaucoma and 20 control subjects. Raw images were exported and the thickness of the photoreceptor/RPE (REC+), inner nuclear (INL), RGC plus inner plexiform (RGC+), and retinal nerve fiber (RNFL) layers was measured with a manual segmentation procedure aided by a computer program. All patients had visual fields obtained with standard automated perimetry (SAP). The patients were divided into two groups based upon SAP foveal sensitivity: low (<34dB) and high (>34dB) sensitivity.

Results: : For the controls, the thickness profiles of the 4 layers along the horizontal meridian were consistent with known retinal anatomy. The thickness of the INL and REC+ layers were similar in all 3 groups. The thickness of the RGC+ layer and RNFL of the high sensitivity and control groups were similar. However, these layers were significantly thinner for the low sensitivity group (see figure), indicating there is a qualitative agreement between RGC+ thickness and field sensitivity. Further, a comparison of the local RGC+ layer thickness to local 10-2 visual field sensitivity in 3 glaucoma eyes provided additional evidence for this agreement.

Conclusions: : Local measures of RGC layer thickness can be obtained from fdOCT scans using a computer-aided manual segmentation procedure and these measures show a qualitative agreement with visual field sensitivity.

Keywords: ganglion cells • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • visual fields 
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