April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
The Normal Thickness of the Ganglion Cell Complex in the Macula measured with RTVue OCT
Author Affiliations & Notes
  • M. Fingeret
    Optometry, VA NY Health Care System, Brooklyn, New York
    SUNY Optometry, New York, New York
  • M. Sinai
    Clinical Affairs, Optovue, inc, Freemont, California
  • D. F. Garway-Heath
    NIHR BMRC for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • D. Greenfield
    Ophthalmology, Bascom Palmer Eye Insitute, Palm Beach Gardens, Florida
  • R. Varma
    Ophthalmology, Doheny Eye Insitutute, Los Angeles, California
  • J. Liebmann
    Ophthalmology, Manhattan Eye and Ear Hospital, New York, New York
  • J. S. Schulman
    Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
  • C. Girkin
    Ophthalmology, University of Alabama in Birmingham, Birmingham, Alabama
  • Optovue Normative Database Study Group
    Optometry, VA NY Health Care System, Brooklyn, New York
  • Footnotes
    Commercial Relationships  M. Fingeret, Carl Zeiss Meditec, C; Optovue, R; M. Sinai, Optovue, inc, E; D.F. Garway-Heath, None; D. Greenfield, None; R. Varma, None; J. Liebmann, None; J.S. Schulman, None; C. Girkin, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 3322. doi:
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    • Get Citation

      M. Fingeret, M. Sinai, D. F. Garway-Heath, D. Greenfield, R. Varma, J. Liebmann, J. S. Schulman, C. Girkin, Optovue Normative Database Study Group; The Normal Thickness of the Ganglion Cell Complex in the Macula measured with RTVue OCT. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3322.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To determine the normal thickness of the ganglion cell complex in the macula region measured with the RTVue, a fourier-domain OCT, and to evaluate the relationship with age and possible ethnic differences.

Methods: : 861 eyes were collected at 15 clinical sites worldwide with the average age being 50.7 years old (range 19-82 years). Eligible subjects were over 18 years old, free from known ocular pathology, had IOP below 22 mm Hg, and a full visual field test based on the Humphrey 24-2 SITA Standard perimetry. Optic disc appearance was not used as an exclusion criterion to avoid bias in the database.

Results: : The table lists the mean GCC thickness and standard deviation (SD) by ethnicity. Significant ethnic differences were found (p < .001) even when age effects were taken into account.

Conclusions: : The GCC in the macula may be an important area of interest for detecting early glaucoma. Significant ethnic differences were found in the GCC thickness. Thus it may be important for an instrument to use an ethnic-specific database which automatically adjusts the normative range and cut-offs to account for both age and GCC effects.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • ganglion cells • macula/fovea 

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