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M. Seong, K. Sung, S. Park, J. Choi, M. Kook; Glaucoma Discrimination Capability of Macular Inner Retinal Layer Thickness Assessed by Spectral Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3326.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the glaucoma discrimination capability of macular inner retinal layer (MIRL) thickness measured by spectral domain optical coherence tomography (SD-OCT, RTVue-100)
One randomly chosen eye of 30 glaucoma and 35 healthy subjects were scanned by SD-OCT using MM7, RNFL 3.45 and NHM4 mode. MM7 mode provides MIRL thickness, while RNFL3.45 mode peripapillary RNFL thickness (RNFL1) by circular scanning, NHM4 mode peripapillary RNFL thickness (RNFL2) by resampling of 3dimensional data set. Areas under receiver operating characteristic curves (AUROCs) of average, superior and inferior MIRL and RNFL thicknesses were determined and compared.
Average MIRL, RNFL1 and RNFL2 were significantly different between healthy and glaucomatous eyes (p<0.001, p<0.001, p<0.001). AUROCs of MIRL, RNFL1 and RNFL2 for glaucoma discrimination were 0.781, 0.725, 717 in average, 0.765, 0.705, 0.697 in superior and 0.727, 0.737, 721 in inferior thickness. AUROCs between average MIRL and RNFL1 and RNFL2 were not significantly different each other (p=0.180, p=0.08).
Average MIRL thickness measured by SD-OCT showed comparable glaucoma discrimination capability to average RNFL thickness. MIRL thickness as obtained by SD-OCT can be an alternative to RNFL thickness for detection of glaucoma.
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