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G. C. Massa, V. G. Vidotti, F. Cremasco, A. P. C. Lupinacci, V. P. Costa; Influence of Pupil Dilation on Retinal Nerve Fiber Layer Measurements With Spectral Domain OCT. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3331.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the influence of pupil dilation on retinal nerve fiber layer (RNFL) measurements with Spectral Domain OCT.
29 healthy individuals and 26 glaucoma patients underwent RNFL measurements with the Cirrus HD-OCT Model 4000 (Carl Zeiss, Med Tec Inc, Dublin, CA, USA) pre and 30-40 minutes after pupil dilation with one drop of tropicamide 1%. Average thickness, quadrant thickness and clock-hour thickness measurements were compared with the paired Student’s t test. We also compared the quality scores of the images obtained pre and post pupil dilation.
Mean ages in the glaucoma and control groups were 58.3 + 13.4 years and 41.6 + 16.4 years, respectively (p<0.001). Mean MD values were -6.96 + 6.31 dB in the glaucoma group and -1.26 + 0.79 dB in the control group (p<0.001). There was no statistically significant difference between mean quality scores obtained pre and post dilation neither in the glaucoma group (p=0.232) nor in the control group (p=0.380). There was no statistically significant difference between mean RNFL measurements obtained pre and post pupil dilation neither among normal individuals (p>0.05), nor among glaucoma patients (p>0.05). Mean RNFL measurements obtained in the glaucoma group were significantly lower than those obtained in the control group (p<0.001).
The results of this study indicate that RNFL measurements obtained with Spectral Domain OCT are not influenced by pupil size.
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