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E. Lee, T.-W. Kim, J.-M. Hwang; Visualization of Early Localized Retinal Nerve Fiber Layer Defects Using Cirrus Spectral Domain OCT: A Comparison with Stratus OCT. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3335.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the visualization of early localized retinal nerve fiber layer (RNFL) defects in Cirrus OCT images and to compare the sensitivity of Cirrus OCT and Stratus OCT in detection of such defects.
Thirty-six patients having localized RNFL defects less than 20 degree-width in red-free fundus photography were included in this study. Patients were scanned with Cirrus OCT and Stratus OCT.
RNFL defects were visualized in the Cirrus OCT Deviation-from-Normal map in 34 (94.4%) eyes. The defects visualized in the map showed good topographic agreement with defect location as shown by red-free fundus photography in 31 (86.1%) eyes. Other Cirrus OCT parameters showed higher sensitivity than the corresponding parameters of Stratus OCT, with a sensitivity of 86.1% vs 50.0% using the parameter of abnormal segment at the 5% level in the TSNIT curve, 69.4% vs. 41.7% using the parameter of ≥one clock-hour abnormality at the 5% level, 50.0% vs. 22.2% using the parameter of ≥one quadrant abnormality at the 5% level, and 33.3% vs. 5.6% using the parameter of abnormal 360° average thickness at the 5% level.
Cirrus OCT visualizes early localized defects, often not detected with Stratus OCT, with excellent sensitivity and good topographic agreement with red-free fundus photography.
Red-free fundus photography, Cirrus OCT Deviation-from-Normal maps, and Stratus OCT findings (TSNIT curve and circular diagrams), in six cases of localized retinal nerve fiber layer defects less than 20 degrees in width as identified by red-free fundus photography. The defects visualized in the Cirrus OCT Deviation-from-Normal maps (arrowheads) show excellent topographic agreement with defect locations seen by photography (white arrows).
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