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J. Jeoung, K. Park, T.-W. Kim, D. Kim; Comparison of the Cirrus Spectral Domain OCT and Stratus OCT to Detect Localized Retinal Nerve Fiber Layer Defects in Preperimetric Glaucoma. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3339.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate and compare the diagnostic abilities of the Cirrus and Stratus optical coherence tomography (OCT) to detect localized retinal nerve fiber layer (RNFL) defects in patients with normal standard automated perimetry results.
Fifty-five eyes of 55 subjects with preperimetric localized RNFL defects based on red-free fundus photography and 55 normal control eyes of 55 age- and sex-matched subjects were enrolled from the Glaucoma Clinic of Seoul National University Hospital. All individuals underwent the Cirrus OCT and Stratus OCT within a 1-month period. Areas under the receiver operating characteristic curves (AUCs) were calculated and compared for parameters reported as continuous variables. The sensitivity and specificity of various OCT parameters for detecting preperimetric localized RNFL defects was calculated.
There was no statistically significant difference between the AUCs for the best parameters from the Cirrus OCT (inferior thickness, AUC=0.728) and Stratus OCT (7 o’clock sector, AUC=0.760) (P=0.477). The sensitivity of the various Cirrus OCT parameters with the criterion of abnormal at the 5% level ranged from 21.0% to 87.1%, and that of the Stratus OCT parameters ranged from 4.8% to 30.7%. The highest sensitivity of the Cirrus OCT and Stratus OCT was obtained when using the RNFL thickness deviation map (sensitivity 87.1% and specificity 61.8%) and the TSNIT plot (sensitivity 30.7% and specificity 85.5%), respectively.
The sensitivity of Cirrus OCT RNFL thickness parameters for detecting preperimetric localized RNFL defects was generally higher than that of Stratus OCT parameters. Our results suggest that the RNFL analysis by Cirrus OCT has more diagnostic potentials for identifying preperimetric RNFL defects.
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