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K. Sung, S. Park, S. Kim, M. S. Kook; Comparison of Glaucoma Diagnostic Capabilities Assessed by Cirrus and Stratus Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3344.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate and compare the glaucoma diagnostic capabilities between time domain (Stratus) and spectral domain (Cirrus) optical coherence tomography (OCT).
Fifty five glaucoma and sixty age-matched healthy subjects were tested by Stratus OCT (fast RNFL scan mode) and Cirrus OCT (optic disc cube mode) at the same visit. Areas under receiver operating characteristic curves (AUROCs) of average retinal nerve fiber layer (RNFL) thickness and RNFL thickness at quadrants and sectors were determined and compared between Stratus OCT and Cirrus OCT in early (MD ≥ -6dB) and moderate to advanced (MD < -6 dB) stage of glaucoma, respectively.
Cirrus OCT demonstrated greater AUROC than Stratus OCT in average RNFL thickness (0.916 vs 0.950, p=0.03). Cirrus OCT also showed higher AUROCs in average, temporal and superior quadrants, 10, 11, 12 clock hour RNFL thickness measurements in early stage of glaucoma. Diagnostic capabilities were not significantly different between two OCTs in moderate to advanced stage of glaucoma.
Cirrus OCT showed equivalent or better discrimination glaucoma capability than Stratus OCT and this result was more evident in early stage of glaucoma in our seris. Our findings suggest improved technology of Spectral domain OCT may provide a comparable or better diagnostic capability than Stratus OCT in earlier detection of glaucoma.
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