Abstract
Purpose: :
To report the incidence and clinical course of sterile endophthalmitis associated with office-based intravitreal injection of Triesence (triamcinolone acetonide).
Methods: :
This is a retrospective, consecutive, single center case series. All patients received at least one injection of Triesence. Patients were treated with 4-8 mg/ 0.1-0.2ml of intravitreal "preservative free" Triesence. The procedure was performed with sterile gloves, 10% Povidone Iodine prep, a sterile lid speculum and antibiotic drops. Follow-up after each injection was at least 2 months.
Results: :
A total of 38 injections of intravitreal Triesence were given during the study period. Sterile endophthalmitis developed in 2 patients (5.3%). Both patients experienced a dramatic, painless decrease in pre-treatment Snellen visual acuity (VA) from 20/60 and 20/100 to the Hand Motion level within 24 hours of their injection. A sterile hypopyon with dense vitreous inflammation was observed in both patients. The VA improved to baseline at 2 months after injection in both patients.
Keywords: endophthalmitis • corticosteroids • drug toxicity/drug effects