April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
Aqueous Humor Pigment Epithelium-derived Factor Levels in Patients With Acute Anterior Uveitis
Author Affiliations & Notes
  • A. Quijada
    IOVA, Valencia, Spain
  • D. Salom
    Hospital la Fe, Valencia, Spain
  • S. Garcia-Delpech
    Hospital la Fe, Valencia, Spain
  • P. Udaondo
    IOVA, Valencia, Spain
  • M. Diaz-Llopis
    Hospital la Fe, Valencia, Spain
  • Footnotes
    Commercial Relationships  A. Quijada, None; D. Salom, None; S. Garcia-Delpech, None; P. Udaondo, None; M. Diaz-Llopis, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 3575. doi:
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      A. Quijada, D. Salom, S. Garcia-Delpech, P. Udaondo, M. Diaz-Llopis; Aqueous Humor Pigment Epithelium-derived Factor Levels in Patients With Acute Anterior Uveitis. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3575.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : Pigment epithelium-derived factor (PEDF) is an anti-angiogenic/neurotropic dual functional factor, and recently it was also shown to mediate anti-oxidative action. The purpose of this study was to evaluate the levels of PEDF in the aqueous humor in eyes with acute anterior uveitis (AAU).

Methods: : A prospective, comparative control study. Aqueous humor was collected from 20 eyes of 20 patients with AAU. The level of PEDF was determined with a commercially available enzyme-linked immunoabsorbent assay kit. The control group comprised 20 aqueous samples from 20 patients about to undergo cataract surgery and without any other ocular or systemic diseases.

Results: : The concentration of PEDF in aqueous humor was markedly higher in patients with UUA than in control subjects (Mann-Withney U test, P< 0.001). The level of PEDF was 6291637.70 ± 8564836.48 (mean ± SD) pg/ml in eyes with UUA and 449178.10 ± 158670.19 pg/ml in the eyes of the control group.

Conclusions: : The aqueous humor PEDF level is increased in eyes with AAU, and may be increased as a countersystem against inflammation in AAU.

Keywords: aqueous • clinical laboratory testing • inflammation 

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