April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
Relationship Between Rubella Virus and Fuchs Heterochromic Iridocyclitis
Author Affiliations & Notes
  • J. Suzuki
    Department of Ophthalmology, Tokyo Medical Univ Hospital, Shinjuku-Ku, Japan
  • H. Goto
    Department of Ophthalmology, Tokyo Medical Univ Hospital, Shinjuku-Ku, Japan
  • K. Komase
    Department of Virology III, National Institute of Infectious Disease, Shinjuku-Ku, Japan
  • Footnotes
    Commercial Relationships  J. Suzuki, None; H. Goto, None; K. Komase, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 3576. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J. Suzuki, H. Goto, K. Komase; Relationship Between Rubella Virus and Fuchs Heterochromic Iridocyclitis. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3576.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : To determine whether rubella virus is involved in the pathogenesis of Fuchs heterochromic iridocyclitis (FHI).

Methods: : Eight patients (8 eyes) with FHI based on characteristic ocular manifestations and 8 control subjects were studied. Aqueous humor (AH) samples from all patients and one vitreous sample from FHI patients were analyzed for intraocular antibody production against rubella virus by calculation of the Goldmann-Witmer coefficient (GWC). Viral detection by nested polymerase chain reaction and isolation was examined in 3 FHI patients. In addition to laboratory examinations, medical history of rubella virus vaccination was also questioned.

Results: : All patients with FHI had an intraocular synthesis of rubella virus antibodies (GWC > 6). Antibody production from vitreous sample in patients with FHI also revealed high index (GWC = 30.6). GWC value from all control subjects revealed under calculation. The rubella genome was detected in 2 of 3 patients and virus was isolated from 1 of 3 patients with FHI. There were no patients with FHI who had been vaccinated against rubella.

Conclusions: : A relationship between FHI and rubella virus was strongly suggested by laboratory data. Vaccination against rubella virus may be effective to prevent from the development of FHI.

Keywords: uveitis-clinical/animal model • pathology: human • bacterial disease 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.