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L. Guilbert Vertiz, S. Groman-Lupa, M. Pedroza-Seres, S. Voorduin, M. C. Jimenez-Martinez; Differential Expression of Cell Migration Markers on T cells in Uveitis Patients. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3578.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate CD8+CD57+ T cell frequency in uveitis patients, the expression of cell migration markers on T cells, and to correlate the immunological data with the ocular findings.
Uveitis patients were included. The expression of CD8, CD57, CD103, CD108, CCR9, CLA were assessed by flow cytometry on peripheral blood mononuclear cells. Data were analized with Sigma-Stat software. The correlations were performed using Spearman or Pearson correlations. Differences were considered statistically when p < 0.05
CD8+CD57+ T cell frequency was increased in uveitis patients. Expression of CD103(p=0.02), CD108(p=0.03), CCR9(p<0.001) and CLA(p=0.01) on T cells was statistically significant in panuveitis patients than in intermediate uveitis patients. Patients with more clinical punctuation showed significant correlation with the expression of CLA(r=-1, p=0.0001) and CD8(r=-1, p=0.008). A positive correlation was observed in intermediate uveitis patients, when CD108 expression was associated with CCR9 expression (r= 0.9, p=0.03) on T cells
CD8+CD57+ T cell frequency was increased in uveitis patients. T cells from intermediate uveitis patients were mainly CD108+CCR9+, suggesting eye homing. T cells from panuveitis patients were mainly CD103+CD108+CCR9+CLA+, suggesting both, eye and skin homing. Clinical-immunological correlation was significant only in panuvetis patients. CLA/CD8 could be biological markers of intraocular immunological activity.Acknowledgments: This work was partially supported by a grant from CONACyT 71291 and Fundacion Conde de Valenciana
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