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P. Topcu Yilmaz, N. Atakan, B. Bozkurt, M. Irkec, L. Mesci, D. Aban, I. Tezcan; Determination of Tear and Serum Inflammatory Cytokines in Patients with Rosacea Using Luminex Technology. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3592.
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To compare the levels of inflammatory cytokines in serum and tear fluid samples between the rosacea subjects and healthy controls.
Thirty patients with rosacea and 22 healthy controls were included in the study. All subjects underwent a dermatological and ophthalmological examination. Serum and minimally stimulated tear samples were obtained from each subject and Luminex technology was used to measure the interleukin (IL)-1, IL-6, IL-8, IL-10, monocyte chemotactic protein-1 (MCP-1), macrophage inhibitory protein-1 (MIP-1), epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) cytokine levels.
Blepharitis, conjunctival hyperemia, meibomian gland dysfunction and telengiectasia were observed in 53.1%, 56.3%, 37.5% and 21.9% of the rosacea group, respectively. Serum IL-8 level was significantly higher in the rosacea group (15.53±67.83 pg/ml) than the control group (6.56±10.35 pg/ml) (p=0.03). Tear concentrations of IL-10 and VEGF were lower in the rosacea group (42.82±39.63 and 390.21±140.91 pg/ml, respectively) than the control group (202.64±546.03 and 524.88±192.39 pg/ml, respectively) (p<0.001 and p=0.005, respectively).
Increased level of serum IL-8, which is a potent chemotactic cytokine, might support the role of infectious agents in the pathogenesis of rosacea. The cytokine levels show a high variation within the population; therefore bigger sample size is needed to confirm the association of cytokines with rosacea.
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